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Isochromenes from the Nicotiana tabacum-Derived Endophytic Fungus Aspergillus versicolor and Their Bioactivities

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Chemistry of Natural Compounds Aims and scope

Two new isochromenes, 5-methoxy-3-methyl-7-prenyl-1H-isochromene (1) and 7-(3-hydroxypropyl)-5-methoxy-3-methyl-1H-isochromene (2), along with four known ones (3–6) were isolated from the fermentation products of the Nicotiana tabacum-derived endophytic fungus Aspergillus versicolor. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were evaluated for their anti-tobacco mosaic virus (anti-TMV) and anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activities. The results showed that compounds 1 and 2 exhibited potential anti-TMV activities with inhibition rates of 36.5 and 42.2%, respectively, and also showed good anti-MRSA activities with IZD of 16.8 ± 2.2 and 20.6 ± 2.5 mm, respectively.

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Acknowledgment

This project was supported financially by the National Natural Science Foundation of China (No. 21967021), the Foundation of Chemical and Biological Innovation Studio of Yunnan Industrial Co., Ltd., the Foundation of Yunnan Tobacco Industry Co., Ltd. (No. 2020CP01), and the Foundation of Yunnan Innovative Research Team (2019HC020).

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Authors and Affiliations

  1. Yunnan Key Laboratory of Tobacco Chemistry, China Tobacco Yunnan Industrial Co., Ltd., 650231, Kunming, P. R. China

    Hua-Yin Liu, Feng-Xian Yang, Jia-Meng Dai, Meng-Jie Liang, Wen Xiong & Jian-Duo Zhang

  2. School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, 650500, Kunming, P. R. China

    Hua-Yin Liu, Meng-Jie Liang & Liang Deng

  3. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, 650031, Kunming, P. R. China

    Feng-Xian Yang, Jia-Meng Dai, Qi-Li Mi, Xue-Mei Li, Kai Wang & Qiufen Hu

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  1. Hua-Yin Liu
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Correspondence to Qiufen Hu or Jian-Duo Zhang.

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Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2023, pp. 38–41.

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Liu, HY., Yang, FX., Dai, JM. et al. Isochromenes from the Nicotiana tabacum-Derived Endophytic Fungus Aspergillus versicolor and Their Bioactivities. Chem Nat Compd 59, 41–45 (2023). https://doi.org/10.1007/s10600-023-03913-z

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  • DOI: https://doi.org/10.1007/s10600-023-03913-z

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