Skip to main content
SpringerLink
Log in

Coumarin-Xanthone Derivatives with Hepatoprotective Activities from Pyrethrum tatsienense

  • Published:
Chemistry of Natural Compounds Aims and scope

A new coumarin-xanthone derivative, named 1,3-dihydroxy-2-methoxy-6′-(11′,12′-dimethylchromene-4′,5′-coumarin)-7′′-(4′′-hydroxybenzyl)-10-methylenexanthone (1), along with five known coumarin or xanthone derivatives 2–6 were isolated from Pyrethrum tatsienense (Bureau & Franch.) Ling ex C. Shih for the first time. Their structures were elucidated by their comprehensive spectroscopic data and reported references. Compounds 1–6 were evaluated for their hepatoprotective activities on human L-02 cells in vitro with Bifendatatum as the positive control. Among them, compounds 1, 2, and 6 exhibited moderate promotive effects on the proliferation of L-02 cells and certain hepatoprotective effects on CCl4-induced injury of L-02 cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. C. Z. Zhu, C. C. Zhu, M. Hu, A. Z. Wu, Z. D. Bariu, and S. Q. Kangsa, J. Intercult. Ethnopharmacol., 3, 123 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Y. Y. Xia, C. C. Zhu, C. Z. Lin, Y. Y. He, S. L. Q. M. Kangsa, and Z. R. D. W. Beiri, J. Chin. Med. Mater., 41, 1609 (2018).

    Google Scholar 

  3. K. J. Xu, Y. A. P. Bai, Z. M. Dawa, M. K. Wang, and L. S. Ding, Lishizhen Med. Mater. Med. Res., 21, 3018 (2010).

    CAS  Google Scholar 

  4. R. R. Wei, Q. G. Ma, G. Y. Zhong, and Z. P. Sang, Chem. Nat. Compd., 56, 224 (2020).

    Article  CAS  Google Scholar 

  5. A. M. Yang, X. Liu, R. H. Lu, and Y. P. Shi, Pharmazie, 61, 70 (2006).

    CAS  PubMed  Google Scholar 

  6. Y. Chen, Y. Du, H. D. Teng, H. F. Nian, Q. X. Lu, and G. Z. Yang, J. South-Central Univ. Natl., 39, 483 (2020).

    Google Scholar 

  7. Q. X. Lu, H. Xiong, Y. Du, H. L. Teng, X. Chen, Y. Chen, and G. Z. Yang, Phytochem. Lett., 40, 130 (2020).

    Article  CAS  Google Scholar 

  8. B. Xie, J. Gu, R. Tan, and Y. H. Cao, China Pharm., 25, 260 (2014).

    CAS  Google Scholar 

  9. L. Zhang, D. Y. Zhang, Z. Dun, and Y. L. Liu, J. Jiangxi Coll. Trad. Chin. Med., 21, 61 (2009).

    Google Scholar 

  10. H. Y. Yan, Y. F. Li, and W. Qian, J. Anhui Agric. Sci., 39, 12151 (2011).

    Google Scholar 

  11. H. Y. Yan, Y. F. Li, and W. Qian, West. China J. Pharm. Sci., 26, 354 (2011).

    Google Scholar 

  12. T. Karunakaran, G. C. L. Ee, K. H. Tee, I. S. Ismail, N. H. Zamakshshari, and W. M. Peter, Phytochem. Lett., 17, 131 (2016).

    Article  CAS  Google Scholar 

  13. F. L. Luo, H. Sugita, K. Muraki, S. Saeki, S. Chaipech, Y. Pongpiriyadacha, O. Muraoka, and T. Morikawa, Fitoterapia, 148, 104780 (2021).

    Article  CAS  PubMed  Google Scholar 

  14. D. F. Dibwe, S. Awale, S. Kadota, and Y. Tezuka, Tetrahedron Lett., 53, 6186 (2012).

    Article  CAS  Google Scholar 

  15. K. H. Lee, H. B. Chai, P. A. Tamez, J. M. Pezzuto, G. A. Cordell, K. K. Win, and M. T. Wa, Phytochemistry, 64, 535 (2003).

    Article  CAS  PubMed  Google Scholar 

  16. Q. G. Ma, R. R. Wei, Z. P. Sang, and J. H. Dong, Fitoterapia, 149, 104812 (2021).

    Article  CAS  PubMed  Google Scholar 

  17. Q. G. Ma, R. R. Wei, and Z. P. Sang, Nat. Prod. Commun., 15, 1 (2020).

    Google Scholar 

  18. Q. G. Ma, R. R. Wei, B. Zhou, Z. P. Sang, W. M. Liu, and Z. L. Cao, Nat. Prod. Res., 33, 457 (2019).

    Article  CAS  PubMed  Google Scholar 

  19. Q. G. Ma, R. R. Wei, and Z. P. Sang, Z. Naturforsch. C., 75, 327 (2020).

  20. X. J. Yuan, L. Lin, X. Q. Zhang, and S. D. Deng, Phytochem. Lett., 7, 137 (2014).

    Article  CAS  Google Scholar 

  21. R. R. Wei, M. H. He, Z. P. Sang, J. H. Dong, and Q. G. Ma, Fitoterapia, 156, 105090 (2022).

    Article  CAS  PubMed  Google Scholar 

  22. Q. G. Ma, R. R. Wei, X. D. Zhang, Z. P. Sang, J. H. Dong, Q. X. Lu, H. F. Huang, D. M. Guo, and L. Jiang, Fitoterapia, 146, 104733 (2020).

    Article  CAS  PubMed  Google Scholar 

  23. R. R. Wei, Q. G. Ma, G. Y. Zhong, J. W. He, and Z. P. Sang, J. Ethnopharmacol., 253, 112685 (2020).

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgment

This work was supported by the Scientific Research Project of Jiangxi Administration of Traditional Chinese Medicine (No. 2019A018) and the Doctoral Research Initiation Fund Project of Jiangxi University of Traditional Chinese Medicine (No. 2018BSZR010).

Author information

Authors and Affiliations

  1. Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Key Laboratory of Modern Preparation of Traditional Chinese Medicine of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, 330004, Nanchang, Jiangxi, P. R. China

    Rongrui Wei & Qinge Ma

Authors
  1. Rongrui Wei
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Qinge Ma
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Qinge Ma.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2023, pp. 34–37.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wei, R., Ma, Q. Coumarin-Xanthone Derivatives with Hepatoprotective Activities from Pyrethrum tatsienense. Chem Nat Compd 59, 36–40 (2023). https://doi.org/10.1007/s10600-023-03912-0

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10600-023-03912-0

Keywords

Search

Navigation