A previously undescribed anthraquinone-aurone adduct 1, named 8-(4′-hydroxy-3′,5′-dimethoxyphenyl)-12-hydroxy-7-(6′′,7′′-dimethylfuran-2′′-one)-9,16-anthraquinone-furochromene-3,2′′-dione, was isolated from the fruits of Cucumis bisexualis. Its structure was determined by comprehensive spectroscopic data and references. Compound 1 was evaluated for its inhibitory effect against the increase in AST and ALT levels in H2O2-induced HepG2 cells in the range of their maximum nontoxic concentration. Compound 1 exhibited moderate hepatoprotective activities in vitro.
References
C. Q. Li and Z. Y. Wang, China Health Care Nutr., 5, 44 (2017).
Q. G. Ma, R. R. Wei, and Z. P. Sang, Nat. Prod. Commun., 15, 1 (2020).
Q. G. Ma, R. R. Wei, and Z. P. Sang, Z. Naturforsch. C, 75, 327 (2020).
Q. G. Ma, R. R. Wei, M. Yang, X. Y. Huang, F. Wang, Z. P. Sang, W. M. Liu, and Q. Yu, J. Agric. Food Chem., 66, 5540 (2018).
Q. G. Ma, R. R. Wei, and Z. P. Sang, J. Food Biochem., 44, e13264 (2020).
N. T. T. Mai, N. X. Hai, D. H. Phu, P. N. H. Trong, and N. T. Nhan, Phytochem. Lett., 5, 647 (2012).
M. Namikoshi, H. Nakata, and T. Saitoh, Phytochemistry, 26, 1831 (1987).
J. Ko, W. Yeh, W. C. Huang, and H. Y. Yang, J. Food Sci., 84, 1586 (2019).
H. Nyblom, U. Berggren, J. Balldin, and R. Olsson, Alcohol Alcoholism, 39, 336 (2004).
Q. G. Ma, R. R. Wei, D. L. Shang, Z. P. Sang, W. M. Liu, and Z. L. Cao, Pak. J. Pharm. Sci., 32, 2059 (2019).
Q. G. Ma, R. R. Wei, B. Zhou, Z. P. Sang, W. M. Liu, and Z. L. Cao, Nat. Prod. Res., 33, 457 (2019).
R. R. Wei, Q. G. Ma, G. Y. Zhong, J. W. He, and Z. P. Sang, J. Ethnopharmacol., 253, 112685 (2020).
Q. G. Ma, R. R. Wei, X. D. Zhang, Z. P. Sang, J. H. Dong, Q. X. Lu, H. F. Huang, D. M. Guo, and L. Jiang, Fitoterapia, 146, 104733 (2020).
X. R. Peng, J. Q. Liu, Z. Han, X. X. Yuan, H. R. Luo, and M. H. Qiu, Food Chem., 141, 920 (2013).
X. R. Peng, J. Q. Liu, C. F. Wang, X. Y. Li, Y. Shu, L. Zhou, and M. H. Qiu, J. Nat. Prod., 77, 737 (2014).
ACKNOWLEDGMENT
This study was supported by Jiangxi Provincial Natural Science Foundation (20202BAB206078).
Author information
Authors and Affiliations
Corresponding author
Additional information
Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2021, pp. 711–713.
Rights and permissions
About this article
Cite this article
Ma, Q., Wei, R. A New Anthraquinone-Aurone Adduct with Hepatoprotective Activity from the Fruits of Cucumis bisexualis. Chem Nat Compd 57, 828–831 (2021). https://doi.org/10.1007/s10600-021-03490-z
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10600-021-03490-z