Renal excretions of the drug Histochrome contained echinochrome, the drug substance; 2(3)-methoxyechinochrome derivatives; and monoglucuronides of 2(3)-methoxy-, 2,3-dimethoxy-, 2,6-dimethoxy-, and 3,6-dimethoxyechinochrome derivatives according to HPLC-MS (high resolution) using a deuterated label.
Similar content being viewed by others
References
O. S. Talalaeva, Ya. F. Zverev, V. M. Bryukhanov, and N. P. Mishchenko, Eksp. Klin. Farmakol., 79, 34 (2016).
O. S. Talalaeva, N. P. Mishchenko, V. M. Bryukhanov, Ya. F. Zverev, V. V. Lampatov, and L. G. Dvornikov, Eksp. Klin. Farmakol., 77, 29 (2014).
a) R. H. Thomson, Naturally Occurring Quinones, 2nd Ed. Academic Press, London, New York, 1971, p. 734; b) 3rd Ed., Chapman and Hall, London, New York, 1987, p. 732; c) 4th Ed., Blackie Academic and Professional, London, New York, 1997, p. 746.
V. F. Anufriev, S. G. Polonik, N. D. Pokhilo, and N. N. Balaneva, Izv. Akad. Nauk, Ser. Khim., 2128 (2003); [V. Ph. Anufriev, S. G. Polonik, N. D. Pokhilo, and N. N. Balanyova, Russ. Chem. Bull. Int. Ed., 52, 2247 (2003)].
Syntheses of Organic Drugs [in Russian], Coll. 1, IL, Moscow, 1949, 604 pp. [Organic Synthesis, Collective, Vol. 1, New York, 1944].
V. F. Anufriev, V. L. Novikov, N. N. Balaneva, G. B. Elyakov, and O. B. Maksimov, RU Pat. 1,821,023 (1993); Byull. Izobret., No. 21 (1993); V. F. Anufriev, G. B. Elyakov, S. G. Polonik, N. D. Pokhilo, O. P. Shestak, A. Ya. Yakubovskaya, S. A. Osadchii, G. A. Tolstikov, and E. E. Shul′ts, RU Pat. 2,277,083, May 27, 2006, Byull. Izobret., No. 15 (2006).
S. G. Polonik, N. D. Pokhilo, V. V. Makhan′kov, and V. F. Anufriev, Chem. Nat. Compd., 44, 93 (2008).
J. H. Bowie, D. W. Cameron, and D. H. Williams, J. Am. Chem. Soc., 87, 5094 (1965).
R. I. Sanchez and F. C. Kauffman, Compr. Toxicol., 9, 109 (2010).
S. G. Polonik, A. M. Tolkach, and N. I. Uvarova, Zh. Org. Khim., 30, 248 (1994).
Acknowledgment
The work was performed using equipment at the Far Eastern Center for Molecular Structure Research (NMR and mass spectrometry) (CMSR, PIBOCh, FEB, RAS).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2023, pp. 22–25.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Zakirova, A.E., Popov, R.S., Makhan’kov, V.V. et al. Structures of Renal Excretions of Histochrome Using a Deuterated Label. Chem Nat Compd 59, 21–25 (2023). https://doi.org/10.1007/s10600-023-03909-9
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10600-023-03909-9