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A New Anti-Endometrial Cancer Diterpenoid Glucoside from Sheareria nana

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Chemistry of Natural Compounds Aims and scope

A new diterpenoid glucoside, 15,16-dihydroxy-4-formyl-neo-clerodane-3,13 (Z)-dien-17-O-β-Dglucopyranosyl (1), was isolated from Sheareria nana S. Moore. The structure was elucidated by spectroscopic data. 1 was evaluated for cytotoxic activities against human endometrial carcinoma cells (Ishikawa and ECC-1). The results suggested that 1 exhibited moderate cytotoxic activity against Ishikawa and ECC-1 cell lines with IC50 values of 6.6 ± 0.2 and 12.1 ± 0.1 μM for 24 h respectively, whereas 1 showed no cytotoxicity against a human hepatocyte cell line. Thus, 1 was a potential choice for the treatment of endometrial carcinoma.

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References

  1. S. J. Henley, E. M. Ward, S. Scott, J. Ma, R. N. Anderson, A. U. Firth, C. C. Thomas, F. Islami, H. K. Weir, D. R. Lewis, R. L. Sherman, M. Wu, V. B. Benard, L. C. Richardson, A. Jemal, K. Cronin, and B. A. Kohler, Cancer, 126, 2225 (2020).

    Article  Google Scholar 

  2. P. Morice, A. Leary, C. Creutzberg, N. Abu-Rustum, and E. Darai, Lancet, 387, 1094 (2016).

    Article  Google Scholar 

  3. Z. X. Xia and Z. Y. Tang, ACS Omega, 6, 10944 (2021).

    Article  CAS  Google Scholar 

  4. Z. X. Xia, L. H. Lu, and L. Li, Chem. Nat. Compd., 56, 1094 (2020).

    Article  CAS  Google Scholar 

  5. C. Z. Gu, Z. Y. Li, S. Q. Huang, Y. Bao, Y. H. Li, P. S. Chen, Z. R. Zhang, S. K. Lai, and R. H. Shan, Flora of China, Science Press, Beijing, 80, 322 (1999).

  6. Z. Y. Tang, J. M. Shen, F. Zhang, J. Y. Liang, and Z. X. Xia, Fitoterapia, 124, 12 (2018).

    Article  CAS  Google Scholar 

  7. Z. Y. Tang and Z. X. Xia, Chem. Nat. Compd., 57, 691 (2021).

    Article  CAS  Google Scholar 

  8. M. D. Alaniya, M. G. Sutiashvili, A. V. Skhirtladze, and M. Z. Getiya, Chem. Nat. Compd., 57, 887 (2021).

    Article  CAS  Google Scholar 

  9. Z. Y. Tang, L. H. Lu, and Z. X. Xia, Drug. Des. Devel. Ther., 14, 3965 (2020).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Emergency and Critical Care Medicine, JinShan Hospital, Fudan University, 201508, Shanghai, P. R. China

    Zhongyan Tang

  2. Department of Pharmacy, School & Hospital of Stomatology, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Tongji University, 399 Middle Yan Chang Road, 200072, Shanghai, P. R. China

    Zhengxiang Xia

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  1. Zhongyan Tang
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  2. Zhengxiang Xia
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Correspondence to Zhengxiang Xia.

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Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2022, pp. 733–735.

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Tang, Z., Xia, Z. A New Anti-Endometrial Cancer Diterpenoid Glucoside from Sheareria nana. Chem Nat Compd 58, 870–873 (2022). https://doi.org/10.1007/s10600-022-03819-2

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  • DOI: https://doi.org/10.1007/s10600-022-03819-2

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