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Triterpenoids, Steroids, and Other Constituents from the Roots of Codonopsis pilosula var. modesta

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Chemistry of Natural Compounds Aims and scope

One new tirucallane-type triterpenoid, codopitirol A (1), has been isolated from the roots of Codonopsis pilosula var. modesta (Nannf.) L. D. Shen, together with fourteen known compounds, including four triterpenoids (2–5), five steroids (6–10), one eudesmane-type sesquiterpenoid (11), one phenylpropanoid (12), one coumarin (13), and two other compounds (14 and 15). The structure of the new compound (1) was determined by HR-ESI-MS and extensive spectroscopic analyses, particularly 1D and 2D NMR, and IR. In addition, compounds 1, 2, and 14 exhibited potential α-glucosidase inhibitory activities with IC50 values of 28.3 ± 2.7, 5.5 ± 0.5, 27.4 ± 1.5 μM, respectively.

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Acknowledgment

We are grateful to the National Key Research and Development Program of China (Nos. 2018YFC1706300 and 2018YFC1706304), the Natural Science Foundation of Gansu Province, China (Nos. 21JR7RA477 and 21JR7RA444), and the Science and Technology Project of Lanzhou City (No. 2018-4-61) for their financial support of this research.

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Authors and Affiliations

  1. School of Pharmacy, Lanzhou University, 730000, Lanzhou, P. R. China

    Bing Li, Ru-Yue Wang, Mei-Jie Wang, Fang-Di Hu, Dong-Qing Fei & Zhan-Xin Zhang

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  1. Bing Li
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  2. Ru-Yue Wang
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  3. Mei-Jie Wang
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  4. Fang-Di Hu
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Correspondence to Dong-Qing Fei or Zhan-Xin Zhang.

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Published in Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2022, pp. 572–575.

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Li, B., Wang, RY., Wang, MJ. et al. Triterpenoids, Steroids, and Other Constituents from the Roots of Codonopsis pilosula var. modesta. Chem Nat Compd 58, 674–678 (2022). https://doi.org/10.1007/s10600-022-03767-x

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  • DOI: https://doi.org/10.1007/s10600-022-03767-x

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