Claisen–Schmidt reactions of 3-oxoglycyrrhetic acid with aromatic aldehydes in EtOH–NaOH (4N) synthesized 2-arylidene-3-oxo-derivatives in 65–70% yields. The structures of the compounds were confirmed by PMR and 13C NMR spectra using 2D correlation methods.
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The work was financially supported by the RFBR (Project No. 21-53-52004_MNT_a) and a State Task (Topic 122031400282-9) using equipment at the Khimiya CUC.
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Translated from Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2022, pp. 568–571.
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Baltina, L.A., Baltina, L.A., Nugumanov, T.R. et al. Synthesis of 2-Arylidene-3-Oxo-Derivatives of Glycyrrhetic Acid. Chem Nat Compd 58, 669–673 (2022). https://doi.org/10.1007/s10600-022-03766-y
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DOI: https://doi.org/10.1007/s10600-022-03766-y