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Reaction of (2R,4S)-2-alkyl-6-oxohexahydropyrimidine-4-carboxylic acids with phenyl isothiocyanate

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Abstract

Optically pure (2S,4S)-2-alkyl-6-oxo-3-(phenylcarbamothioyl)hexahydropyrimidine-4-carboxylic acids have been synthesized from natural L-asparagine, commercially available aldehydes, and phenyl isothiocyanate. The product structure was confirmed by 1H and 13C NMR data.

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Authors and Affiliations

  1. Institute of Macromolecular Compounds, Russian Academy of Sciences, Bol’shoi pr. V.O. 31, St. Petersburg, 199004, Russia

    D. G. Nasledov, A. Yu. Ershov & V. V. Shamanin

  2. VEKTON Closed Corporation, Suvorovskii pr. 36A, St. Petersburg, 191015, Russia

    V. A. Polukeev

  3. Pavlov Ryazan State Medical University, ul. Vysokovol’tnaya 9, Ryazan, 390026, Russia

    L. Yu. Kuleshova

Authors
  1. D. G. Nasledov
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  2. A. Yu. Ershov
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  3. V. A. Polukeev
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  4. L. Yu. Kuleshova
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  5. V. V. Shamanin
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Corresponding author

Correspondence to A. Yu. Ershov.

Additional information

Original Russian Text © D.G. Nasledov, A.Yu. Ershov, V.A. Polukeev, L.Yu. Kuleshova, V.V. Shamanin, 2015, published in Zhurnal Organicheskoi Khimii, 2015, Vol. 51, No. 4, pp. 569–572.

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Nasledov, D.G., Ershov, A.Y., Polukeev, V.A. et al. Reaction of (2R,4S)-2-alkyl-6-oxohexahydropyrimidine-4-carboxylic acids with phenyl isothiocyanate. Russ J Org Chem 51, 552–555 (2015). https://doi.org/10.1134/S1070428015040156

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  • DOI: https://doi.org/10.1134/S1070428015040156

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