Skip to main content
SpringerLink
Log in

A New Quassinoid from Brucea javanica

  • Published:
Chemistry of Natural Compounds Aims and scope

A new quassinoid, dehydrobruceantinol B (1), was isolated from the seeds of Brucea javanica, together with two known compounds, bruceantinol (2) and bruceine A (3). The structure of the new compound 1 was elucidated by advanced spectrometric methods, including HR-MS, UV, IR, 1D and 2D NMR experiments. The inhibitory effects of 1–3 on nitric oxide production in lipopolysaccharide-activated macrophages were also investigated in this study.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. J. H. Liu, N. Zhao, G. J. Zhang, S. S. Yu, L. J. Wu, J. Qu, S. G. Ma, X. G. Chen, T. Q. Zhang, J. Bai, H. Chen, Z. F. Fang, F. Zhao, and W. B. Tang, J. Nat. Prod., 75, 683 (2012).

    Article  CAS  Google Scholar 

  2. L. Lahrita, K. Moriai, R. Iwata, K. Itoh, and E. Kato, Fitoterapia, 137, 104250 (2019).

  3. Y. Zhan, T. Tana, K. Qian, S. Yang, Y. Feng, and Q. Wen, Nat. Prod. Res., 34, 1186 (2020).

    Article  CAS  Google Scholar 

  4. T. Sakaki, S. Yoshimura, T. Tsuyuki, T. Takahashi, and T. Honda, Chem. Pharm. Bull., 34, 4447 (1986).

    Article  CAS  Google Scholar 

  5. Subeki, H. Matsuura, K. Takahashi, K. Nabeta, M. Yamasaki, Y. Maede, and K. Katakura, J. Nat. Prod., 70, 1654 (2007).

    Article  CAS  Google Scholar 

  6. A. Elkhateeb, M. Yamasaki, Y. Maede, K. Katakura, K. Nabeta, and H. Matsuura, Nat. Prod. Commun., 3, 145 (2008).

    CAS  Google Scholar 

  7. J. Li, D. Y. Zheng, Y. K. Sun, Y. F. Sun, L. Liu, Y. Fan, and L. D. Zhang, Lett. Org. Chem., 14, 368 (2017).

    Google Scholar 

  8. S. M. Kupchan, R. W. Britton, J. A. Lacadie, M. F. Ziegler, and C. W. Sigel, J. Org. Chem., 40, 648 (1975).

    Article  CAS  Google Scholar 

  9. J. Xu, D. Xiao, W. W. Song, L. Chen, W. Y. Liu, N. Xie, F. Feng, and W. Qu, Fitoterapia, 110, 13 (2016).

    Article  CAS  Google Scholar 

  10. L. Zhao, Q. Wen, G. Yang, Z. Huang, T. Shen, H. Li, and D. Ren, Phytomedicine, 23, 114 (2016).

    Article  CAS  Google Scholar 

  11. S. Bawm, H. Matsuura, A. Elkhateeb, K. Nabeta, Subeki, N. Nonaka, Y. Oku, and K. Katakura, Vet. Parasitol., 158, 288 (2008).

    Article  CAS  Google Scholar 

Download references

Acknowledgment

This study is supported by the Department of Science and Technology of Liaoning Province (2020-MS-225).

Author information

Authors and Affiliations

  1. School of Traditional Chinese Medicine, Liaoning University of Traditional Chinese Medicine, 110032, Shenyang, P. R. China

    Jun Li, Yunfeng Sun, Li Liu & Yuan Yuan

  2. School of Pharmacy, North China University of Science and Technology, 063210, Tangshan, P. R. China

    Dayong Zheng

  3. Cancer Therapeutics Program, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA

    Ning Wei

  4. Department of Pharmacy, Shengjing Hospital of China Medical University, 110004, Shenyang, P. R. China

    Qinghua Jiang

Authors
  1. Jun Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dayong Zheng
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ning Wei
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yunfeng Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Li Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yuan Yuan
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Qinghua Jiang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Jun Li or Qinghua Jiang.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2022, pp. 553–555.

Rights and permissions

Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Li, J., Zheng, D., Wei, N. et al. A New Quassinoid from Brucea javanica. Chem Nat Compd 58, 650–652 (2022). https://doi.org/10.1007/s10600-022-03762-2

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10600-022-03762-2

Keywords

Search

Navigation