Two new chromeno[3,2-c]pyridine alkaloids, 9-acetyl-7-methoxy-3-methyl-10H-chromeno[3,2-c]pyridin- 10-one (1) and 8-acetyl-7-methoxy-3-methyl-10H-chromeno[3,2-c]pyridin-10-one (2), were isolated from the whole plants of Thalictrum scabrifolium. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their antibacterial activity. The results showed that both compounds showed high antibacterial activity against 12 microbial strains isolated from the saliva of smokers.
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Acknowledgment
This project was supported financially by the Foundation of China Tobacco Company (110201901021 (JY-08)), the National Natural Science Foundation of China (No. 21762050), the Foundation of Yunnan Tobacco Industry Co. Ltd. (No. 2019JC04), and the Yunnan Innovative Research Team (2019HC020).
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Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2022, pp. 432–434.
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Yin, GY., Zhu, YN., Wu, F. et al. Two New Antibacterial Chromeno[3,2-c]Pyridine Alkaloids from Whole Plants of Thalictrum scabrifolium. Chem Nat Compd 58, 506–510 (2022). https://doi.org/10.1007/s10600-022-03722-w
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DOI: https://doi.org/10.1007/s10600-022-03722-w