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Two New Bioactive Metabolites from Xestospongia sp. with Antimicrobial and Anticancer Activities

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Chemistry of Natural Compounds Aims and scope

The CH2Cl2-MeOH extract of the Red Sea sponge Xestospongia sp. afforded two new compounds (1 and 2) and two previously identified C-30 sterols (3 and 4). The chemical structures of the isolated compounds were deduced by examining their NMR and MS spectral data. The antimicrobial activity evaluation of the isolated compounds showed that all the compounds have moderate to good antibacterial effects against the tested bacteria, while compound 1 displayed reasonable activity towards two pathogenic fungi, Aspergillus niger and Candida albicans. Moreover, metabolite 1 has excellent antitumor activities against lymphoma and Ehrlich cell lines with IC50 values of 0.05 and 0.08 mM, respectively. No toxicity was recorded for 1 and 2 (LC50 = 30 mM) against Artemia salina as test organism.

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References

  1. L. P. Christensen, Molecules, 25, 2568 (2020).

    Article  CAS  Google Scholar 

  2. V. M. Dembitsky and D. O. Levitsky, Nat. Prod. Commun., 1, 405 (2006).

    CAS  Google Scholar 

  3. R. E. Minto and B. J. Blacklock, Prog. Lipid Res., 47, 233 (2008).

    Article  CAS  Google Scholar 

  4. M. Taniguchi, Y. Uchio, K. Yasumoto, T. Kusumi, and T. Ooi, Chem. Pharm. Bull., 56, 378 (2008).

    Article  CAS  Google Scholar 

  5. D. V. Kuklev, A. J. Domb, and V. M. Dembitsky, Phytomedicine, 20, 1145 (2013).

    Article  CAS  Google Scholar 

  6. V. M. Dembitsky, Lipids, 41, 883 (2006).

    Article  CAS  Google Scholar 

  7. X. Zhou, J. Sun, W. Ma, W. Fang, Z. Chen, B. Yang, and Y. Liu, Pharm. Boil., 52, 187 (2013).

    Article  Google Scholar 

  8. S. Hirsh, S. Carmely, and Y. Kashman, Tetrahedron, 43, 3257 (1987).

    Article  CAS  Google Scholar 

  9. L. F. Ling, T. Wang, Y. S. Cai, W. F. He, P. Sun, Y. F. Li, and Q. Huang, Eur. J. Med. Chem., 79, 290 (2014).

    Article  Google Scholar 

  10. A. D. Patil, W. C. Kokke, S. Cochran, T. A. Francis, T. Tomszek, and J. W. Westley, J. Nat. Prod., 55, 1170 (1992).

    Article  CAS  Google Scholar 

  11. N. B. Pham, M. S. Butler, J. N. A. Hooper, R. W. Moni, and R. J. Quinn, J. Nat. Prod., 62, 1439 (1999).

    Article  CAS  Google Scholar 

  12. W. Kokke, C. Tarchini, D. B. Stierle, and C. Djerassi, J. Org. Chem., 44, 3385 (1979).

    Article  CAS  Google Scholar 

  13. I. A. Holder and S. T. Boyce, Burns, 20, 426 (1994).

    Article  CAS  Google Scholar 

  14. B. Meyer, N. Ferrigni, J. Putnam, L. Jacobsen, D. Nichols, and J. McLaughlin, Planta Med., 45, 31 (1982).

    Article  CAS  Google Scholar 

Download references

Acknowledgment

The authors wish to thank Mr. Kamal Al-dahodi (Faculty of Maritime Studies, King Abdulaziz University) for sample collection and identification.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, King Abdulaziz University, PO. Box 80203, Jeddah, 21589, Saudi Arabia

    Rihab F. Angawi & Mona M. Alamri

  2. Department of Chemistry, Faculty of Science, Damietta University, Damietta, Egypt

    Seif-Eldin N. Ayyad

  3. Department of Chemistry, Faculty of Science, University of Ha’il, Ha’il, 81451, Saudi Arabia

    Ahmed A. Alotaibi

  4. Department of Biology, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah, 21589, Saudi Arabia

    Magda M. Aly

  5. Botany Department, Faculty of Science, Kafrelsheikh University, Kafr El Sheikh, 33516, Egypt

    Magda M. Aly

  6. Department of Marine Chemistry, Faculty of Marine Sciences, King Abdulaziz University, P. O. Box 80207, Jeddah, 21589, Saudi Arabia

    Walied M. Alarif

Authors
  1. Rihab F. Angawi
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  2. Mona M. Alamri
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  3. Seif-Eldin N. Ayyad
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  4. Ahmed A. Alotaibi
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  5. Magda M. Aly
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  6. Walied M. Alarif
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Corresponding author

Correspondence to Seif-Eldin N. Ayyad.

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Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2022, pp. 261–264.

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Angawi, R.F., Alamri, M.M., Ayyad, SE.N. et al. Two New Bioactive Metabolites from Xestospongia sp. with Antimicrobial and Anticancer Activities. Chem Nat Compd 58, 301–306 (2022). https://doi.org/10.1007/s10600-022-03664-3

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  • DOI: https://doi.org/10.1007/s10600-022-03664-3

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