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Two New Pterocarpans from Lespedeza tomentosa

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A phytochemical study on the MeOH extract of Lespedeza tomentosa roots led to the discovery of two new pterocarpans (labelled tomentocarpan A and B), along with three known pterocarpans and a flavanone. The structures of the two new compounds were found to be (6aR,11aR)-1-methoxy-8-hydroxy-2′,2′-dimethylpyrano[5′,6′:2,3]-2′′,2′′-dimethylpyrano[6′′,5′′:9,10]pterocarpan (5), and 1-methoxy-8-hydroxy-2′,2′-dimethylpyrano[5′,6′:2,3]-2′′,2′′-dimethylpyrano[6′′,5′′:9,10]pterocarp-6a(11a)-ene (6), based on comprehensive spectral and physical property analyses. Compounds 5 and 6 showed butyrylcholinesterase inhibitory activities with IC50 values of 0.50 and 0.62 mM, respectively.

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Acknowledgment

This study has been performed with the support of a research grant from Kangwon National University in 2018.

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Authors and Affiliations

  1. College of Pharmacy, Kangwon National University, 24341, Chuncheon, Republic of Korea

    Yongsoo Kwon & Heejung Yang

  2. School of Medicine, Kangwon National University, 24341, Chuncheon, Republic of Korea

    Wanjoo Chun

  3. College of Agriculture and Life Science, Kangwon National University, 24341, Chuncheon, Republic of Korea

    Myong Jo Kim

  4. National Center for Natural Products Research, School of Pharmacy, University of Mississippi, Oxford, MS, USA

    Iklas A. Khan

Authors
  1. Yongsoo Kwon
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  2. Heejung Yang
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  3. Wanjoo Chun
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  4. Myong Jo Kim
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  5. Iklas A. Khan
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Corresponding author

Correspondence to Yongsoo Kwon.

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Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2021, pp. 386–388.

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Kwon, Y., Yang, H., Chun, W. et al. Two New Pterocarpans from Lespedeza tomentosa. Chem Nat Compd 57, 451–454 (2021). https://doi.org/10.1007/s10600-021-03385-z

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