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A New Chlorinated Tetralone from Co-Culture of Insect-Pathogenic Beauveria bassiana and Phytopathogenic Nigrospora oryzae

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Chemistry of Natural Compounds Aims and scope

In this study, the co-culture of Nigrospora oryzae and Beauveria bassiana, the pathogenic endophytes in the seeds of Dendrobium officinale, were examined for their antagonistic relationship by the production of metabolite. One new chlorotetralone (1) and five known compounds, murranoic acid A (2), 9,12,13-trihydroxy-10-octadecenoic acid (3), 3,3′-methylenebis(4-hydroxy-6-methyl-2H-pyran-2-one) (4), sclerin (5), and (4S)-4,6,8-trihydroxy-3,4-dihydro-1(2H)-naphthalen-1-one (6), were isolated. Compounds 1–5 showed antifungal activity against B. bassiana with MICs of 256, 128, 2, 32, and 64 μg/mL, and N. oryzae with MICs of 64, 256, 256, 256, and 64 μg/mL. Compound 4 showed significant antifungal activity against co-culture of B. bassiana and N. oryzae with MIC at 1 μg/mL.

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Acknowledgment

This project was supported by the National Natural Science Foundation of China (81660582, 81960640, and 81560571), a Project of the Yunling Scholars of Yunnan Province, and the Program for Changjiang Scholars and Innovative Research Team in University (IRT-17R94).

Zhuo-Xi Zhang and Hai-Yue Yin contributed equally to this work.

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Authors and Affiliations

  1. Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, 650091, Kunming, P. R. China

    Zhuo-Xi Zhang, Hai-Yue Yin, Ya-Bin Yang, Dai-Li Wang, Tong-De Zhao, Cui-Fang Wang, Xue-Qiong Yang & Zhong-Tao Ding

  2. Yunnan Vocational Institute of Energy Technology, Qujing, P. R. China

    Zhuo-Xi Zhang

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  1. Zhuo-Xi Zhang
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  2. Hai-Yue Yin
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  3. Ya-Bin Yang
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  5. Tong-De Zhao
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  7. Xue-Qiong Yang
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  8. Zhong-Tao Ding
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Corresponding authors

Correspondence to Xue-Qiong Yang or Zhong-Tao Ding.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2021, pp. 256–257.

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Zhang, ZX., Yin, HY., Yang, YB. et al. A New Chlorinated Tetralone from Co-Culture of Insect-Pathogenic Beauveria bassiana and Phytopathogenic Nigrospora oryzae. Chem Nat Compd 57, 297–299 (2021). https://doi.org/10.1007/s10600-021-03343-9

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  • DOI: https://doi.org/10.1007/s10600-021-03343-9

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