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Oligandrin, a New Ent-Pimarane Type Diterpenoid and Other Bioactive Constituents from the Leaves of Croton oligandrus†

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Chemistry of Natural Compounds Aims and scope

One new ent-pimarane-type diterpenoid (1), along with 10 known compounds, were isolated from the leaves of Croton oligandrus. Compounds 2 and 3 are reported for the first time from this species. The extract and some of the isolates were tested in vitro for their inhibitory properties toward urease and butyrylcholinesterase enzymes, as well as DPPH radical scavenging potency, respectively. Compound 6 (IC50 = 29.2 μM) was the most active on urease, while compound 4 (IC50 = 18.2 μM) showed the best inhibitory activity against butyrylcholinesterase. The new isolate, compound 1, with an IC50 value of 39.4 μM revealed potent antioxidant activity.

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Acknowledgment

The authors acknowledge The World Academy of Science (TWAS) and the International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, Pakistan for the postdoctoral fellowship number 3240293181 granted to FFYS. The authors also acknowledge the German Academic Exchange Service (DAAD) for financial support to the Yaounde-Bielefeld Graduate school of Natural Products with Antiparasite and Antibacterial Activities (YaBiNaPA Project No. 57316173). They are equally thankful to Dr. Tacham Walter Ndam of The University of Bamenda for the botanical identification.

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Authors and Affiliations

  1. Department of Chemistry, Higher Teachers’ Training College, University of Maroua, P. O. Box 55, Maroua, Cameroon

    Yannick S. F. Fongang

  2. Department of Chemistry, Faculty of Science, The University of Bamenda, P. O. Box 39, Bambili, Cameroon

    Angelbert F. Awantu & Jean J. K. Bankeu

  3. Multi-Disciplinary Research Lab, Bahria University, Medical & Dental College, Karachi City, Sindh, 75500, Pakistan

    Mehreen Lateef

  4. Department of Chemistry, Higher Teacher Training College, University of Yaounde I, P. O. Box 47, Yaounde, Cameroon

    Bruno N. Lenta

  5. ICCBS, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan

    Muhammad S. Ali

  6. Department of Chemistry, Faculty of Science, Laboratory of Natural Products and Organic Synthesis, University of Yaounde I, Yaounde, Cameroon

    Silvere A. Ngouela

Authors
  1. Yannick S. F. Fongang
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  2. Angelbert F. Awantu
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  3. Jean J. K. Bankeu
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  4. Mehreen Lateef
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  5. Bruno N. Lenta
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  6. Muhammad S. Ali
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  7. Silvere A. Ngouela
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Correspondence to Yannick S. F. Fongang.

Additional information

Dedicated to Prof. Dr. Viqar Uddin Ahmad (July 1940 – July 2019).

Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2021, pp. 78–83.

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Fongang, Y.S.F., Awantu, A.F., Bankeu, J.J.K. et al. Oligandrin, a New Ent-Pimarane Type Diterpenoid and Other Bioactive Constituents from the Leaves of Croton oligandrus†. Chem Nat Compd 57, 94–100 (2021). https://doi.org/10.1007/s10600-021-03291-4

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  • DOI: https://doi.org/10.1007/s10600-021-03291-4

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