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A New Prenylated Coumarin from Daphne oleoides and its Cytotoxic Activity

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Chemistry of Natural Compounds Aims and scope

A new prenylated coumarin, 7-(4′-methylpentoxy)-2H-1-benzopyran-2-one (1), together with two known coumarins (2, 3), was isolated from the ethyl acetate extract of Daphne oleoides (Thymelaeaceae). Their structures were elucidated on the basis of extensive spectroscopic analysis. The three compounds (1–3) were screened for preliminary cytotoxic activity using MTT assay on human breast cancer (HBL-100), lung cancer (A549), and cervical cancer (HeLa) cell lines, which revealed that the compounds possess in vitro cytotoxic activity with IC50 values ranging between 23.99–49.13 μg/mL.

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References

  1. Y. Wang, G. G. Michael, B. M. Christopher, F. M. Brian, and B. Christopher, Daphne L. sp., Flora of China, Science Press, China and USA, 1994, p. 230.

  2. G. Watt, E. Thurston, and T. Mukhopadhyaya, A Dictionary of the Economic Product of India, III Edition, Cosmo Publications India, Delhi, 1972, p. 26.

  3. M. Tabata, G. Honda, E. Sezik, and E. Yesilada, A Report on Traditional Medicine and Medicinal Plants in Turkey, Kyoto University, 1993.

  4. T. Fujita, E. Sezik, M. Tabata, E. Yesilada, G. Honda, Y. Takeda, T. Tanaka, and Y. Takaishi, Economic Botany, 49, 406 (1995).

    Article  Google Scholar 

  5. S. R. Baquar, Medicinal and Poisonous Plants of Pakistan, Printas Press Karachi, Pakistan, 1989, p. 161.

  6. R. D. Murray, J. Mendez, and S. A. Brown, The Natural Coumarins, Occurrence, Chemistry and Biochemistry, John Wiley and Sons Ltd, New York, 1982.

    Google Scholar 

  7. K. Baba, K. Takeuchi, F. Hamasaki, and M. Kozawa, Chem. Pharm. Bull., 34, 595 (1986).

    Article  CAS  Google Scholar 

  8. A. Ulubelen, B. Terem, and E. Tuzlaci, J. Nat. Prod., 49, 692 (1986).

    Article  CAS  PubMed  Google Scholar 

  9. B. Kreher, H. Wagner, and A. Neszmelyi, Phytochemistry, 29, 3633 (1990).

    Article  CAS  Google Scholar 

  10. M. Niwa, H. Sugino, S. Takashima, T. Sakai, Y. C. Wu, T. S. Wu, and C. S. Kuoh, Chem. Pharm. Bull., 39, 2422 (1991).

    Article  CAS  Google Scholar 

  11. N. Ullah, Z. Ahmed, E. Anis, and A. Malik, Fitoterapia, 69, 280 (1998).

    CAS  Google Scholar 

  12. H. Taninaka, Y. Takaishi, G. Honda, Y. Imakura, E. Sezik, and E. Yesilda, Phytochemistry, 52, 1525 (1999).

    Article  CAS  Google Scholar 

  13. N. Ullah, Phytochemical Investigation of Daphne Oleoides, Doctor of Philosophy Thesis, University of Karachi, Karachi, 1999.

  14. T. Okunishi, N. Takaku, P. Wattanawikkit, N. Sakakibara, S. Suzuki, F. Sakai, T. Umezawa, and M. Shimeda, J. Wood Sci., 48, 237 (2002).

    Article  CAS  Google Scholar 

  15. A. I. Gray, C. J. Meegan, and N. B. O'Callaghan, Phytochemistry, 26, 257 (1986).

    Article  CAS  Google Scholar 

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Acknowledgment

We express sincere gratitude to Director General CCRUM, New Delhi for his administrative and moral support, also Showkat Ahamed Teli, Laboratory Attendant, DSRU, for his technical support in carrying column chromatography.

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Authors and Affiliations

  1. Drug Standardisation Research Unit, RRIUM, Naseem Bagh Campus University of Kashmir, Srinagar, 190006, India

    Muhammad Younus Dar & Seema Akbar

  2. Department of Chemistry, National Institute of Technology, Srinagar, 190006, India

    Tabassum Ara

Authors
  1. Muhammad Younus Dar
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  2. Tabassum Ara
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  3. Seema Akbar
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Correspondence to Muhammad Younus Dar.

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Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2019, pp. 8–9.

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Dar, M.Y., Ara, T. & Akbar, S. A New Prenylated Coumarin from Daphne oleoides and its Cytotoxic Activity. Chem Nat Compd 55, 5–7 (2019). https://doi.org/10.1007/s10600-019-02603-z

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  • DOI: https://doi.org/10.1007/s10600-019-02603-z

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