A new fawcettimine-related alkaloid, 17α-methyllycoflexine (1), together with 14 known analogues, was isolated from the whole plants of Lycopodium japonicum Thunb. Their structures were established by extensive spectroscopic analysis, including NMR and HR-EI-MS experiments. Compound 1 is the second example of derivatives of lycoflexine with an unprecedented additional methyl group at C-17. All the isolated alkaloids were assayed for α-glucosidase inhibitory activity. Only lycodine showed weak α-glucosidase inhibitory activity, whereas the other alkaloids showed no activity.
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Acknowledgment
This investigation was supported by a Grant (No. 21162045) from the Natural Science Foundation of China and a Grant (No. 2009CC018) from Yunnan Province of China for basic research in social development.
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Published in Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2018, pp. 617–618.
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Yang, Q., Zhu, Y., Zhan, R. et al. A New Fawcettimine-Related Alkaloid from Lycopodium japonicum. Chem Nat Compd 54, 729–731 (2018). https://doi.org/10.1007/s10600-018-2456-2
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DOI: https://doi.org/10.1007/s10600-018-2456-2