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Bimolecular Compounds Based on Natural Metabolites

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Chemistry of Natural Compounds Aims and scope

New alkaloid-containing derivatives of the sesquiterpene lactones arglabin, grosshemin, 3,4β-epoxyarglabin, argolide, and parthenolide were prepared for the first time. Their structures were studied using PMR, 13C NMR, and mass spectra and an X-ray crystal structure analysis. Chemo- and regioselective reactions of the sesquiterpene lactones and alkaloids were observed. The synthesized compounds exhibited anthelmintic and hepatoprotective activity and cytotoxicity.

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Authors and Affiliations

  1. Phytochemistry International Scientific and Production Holding, Karaganda, 100009, Republic of Kazakhstan

    S. M. Adekenov, A. S. Kishkentaeva, Zh. R. Shaimerdenova & G. A. Atazhanova

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  1. S. M. Adekenov
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  2. A. S. Kishkentaeva
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  3. Zh. R. Shaimerdenova
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  4. G. A. Atazhanova
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Correspondence to A. S. Kishkentaeva.

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Translated from Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2018, pp. 394–399.

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Adekenov, S.M., Kishkentaeva, A.S., Shaimerdenova, Z.R. et al. Bimolecular Compounds Based on Natural Metabolites. Chem Nat Compd 54, 464–470 (2018). https://doi.org/10.1007/s10600-018-2380-5

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  • DOI: https://doi.org/10.1007/s10600-018-2380-5

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