A series of benzamide derivatives (compounds 1–29) was synthesized based on the lead compound cuminic acid. The crystal structure of compound 11 was characterized by single crystal X-ray diffraction. The antifungal activity of the synthesized compounds was determined against seven plant pathogenic fungi, namely Rhizoctonia solani, Gibberella zeae, Helminthosporium maydis, Sclerotinia sclerotiorum, Botrytis cinerea, Coniothyrium diplodiella, and Coniothyrium lagenarium. Preliminary results indicated that most of them revealed significant antifungal activity. Among them, compound 22 showed the strongest activity and possessed better antifungal activity against H. maydis, S. sclerotiorum, and B. cinerea than carbendazim.
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Acknowledgment
This project was supported by the Scientific Research Fund of Sichuan Provincial Education Department (No. 13ZA0206), the Key Scientific Research Fund of Xihua University (No. Z1013314), the Innovation Fund of Postgraduates of Xihua University (No. YCJJ 2015050), and the Research Center for Advanced Computation, Xihua University.
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Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2017, pp. 945–948.
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Yang, J., Gao, Y., Liu, H. et al. Synthesis and Antifungal Activity of Cuminic Acid Derivatives. Chem Nat Compd 53, 1112–1116 (2017). https://doi.org/10.1007/s10600-017-2212-z
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DOI: https://doi.org/10.1007/s10600-017-2212-z