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A New Xanthone and Anti-Inflammatory Constituents of Garcinia subelliptica

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Chemistry of Natural Compounds Aims and scope

A new xanthone, garcisubellone (1), has been isolated from the roots of Garcinia subelliptica, together with three known compounds, subelliptenone E (2), 1,5-dihydroxy-3-methoxyxanthone (3), and 1,4,5-trihydroxyxanthone (4). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Garcisubellone (1) and 1,4,5-trihydroxyxanthone (4) exhibited potent inhibition, with IC50 values of 18.3 ± 2.2 and 15.6 ± 2.8 μM, respectively, against formyl-L-methionyl-L-leucyl-Lphenylalanine (fMLP)-induced superoxide anion (O2·–) generation.

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Acknowledgment

This research was supported by a grant from the Ministry of Science and Technology, Taiwan (NSC 101-2320-B-127-001-MY3), awarded to Prof. J.-J. Chen.

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Authors and Affiliations

  1. Faculty of Pharmacy, School of Pharmaceutical Sciences, National Yang-Ming University, 112, Taipei, Taiwan

    Jih-Jung Chen

  2. Department of Medical Research, China Medical University Hospital, 404, Taichung, Taiwan

    Jih-Jung Chen

  3. Department of Pharmacy, Tajen University, 907, Pingtung, Taiwan

    Ming-Chi Hung

  4. Graduate Institute of Natural Products, School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, 333, Taoyuan, Taiwan

    Hsiang-Ruei Liao

  5. Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, 404, Taichung, Taiwan

    Yueh-Hsiung Kuo

  6. Department of Medical Education and Research, Kaohsiung Veterans General Hospital, 813, Kaohsiung, Taiwan

    Chih-Wen Shu

  7. National Museum of Marine Biology and Aquarium, 944, Pingtung, Taiwan

    Ping-Jyun Sung

  8. School of Pharmacy, College of Pharmacy, China Medical University, 404, Taichung, Taiwan

    Yun-Ping Lim

  9. Chung-Jen Junior College of Nursing, Health Sciences and Management, 600, Chiayi, Taiwan

    Wen-Lung Kuo

  10. School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, 807, Taichung, Taiwan

    Lin-Yang Cheng & Sin-Ling Wang

  11. National Taichung First Senior High School, 404, Taichung, Taiwan

    Jui-Jen Wu

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  1. Jih-Jung Chen
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  2. Ming-Chi Hung
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  3. Hsiang-Ruei Liao
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  4. Yueh-Hsiung Kuo
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  5. Chih-Wen Shu
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  6. Ping-Jyun Sung
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  7. Yun-Ping Lim
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  8. Wen-Lung Kuo
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  9. Lin-Yang Cheng
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  10. Sin-Ling Wang
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  11. Jui-Jen Wu
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Corresponding author

Correspondence to Jih-Jung Chen.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2017, pp. 553–555.

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Chen, JJ., Hung, MC., Liao, HR. et al. A New Xanthone and Anti-Inflammatory Constituents of Garcinia subelliptica . Chem Nat Compd 53, 649–652 (2017). https://doi.org/10.1007/s10600-017-2082-4

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  • DOI: https://doi.org/10.1007/s10600-017-2082-4

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