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New Labdane-Type Diterpenoid and Cytotoxic Constituents of Hedychium coronarium

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A new labdane-type diterpenoid, hedychiumin (1), has been isolated from the aerial part of Hedychium coronarium, together with five known compounds, (+)-coronarin A (2), (E)-15,16-bisnorlabda-8(17),11-dien-13-one (3), calcaratarin A (4), β-sitostenone (5), and stigmasta-4,22-dien-3-one (6). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, hedychiumin (1) exhibited cytotoxicity, with IC50 value of 4.74 μg/mL, against P388D1 cell line.

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Acknowledgment

This research was supported by a grant from the Ministry of Science and Technology, Taiwan (NSC 101-2320-B-127-001-MY3), awarded to Prof. J.-J. Chen. This work was also supported by the grant from the Zuoying Branch of Kaohsiung Armed Forces General Hospital (ZBH 104-21).

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Authors and Affiliations

  1. Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-Sen University, 80424, Kaohsiung, Taiwan

    Li-Chai Chen & Zhi-Hong Wen

  2. Department of Pharmacy of Zuoying Branch of Kaohsiung Armed Forces General Hospital, 81342, Kaohsiung, Taiwan

    Li-Chai Chen & Pei-Yu Chen

  3. National Museum of Marine Biology and Aquarium, 94450, Pingtung, Taiwan

    Ping-Jyun Sung

  4. Department of Medical Education and Research, Kaohsiung Veterans General Hospital, 81362, Kaohsiung, Taiwan

    Chih-Wen Shu

  5. Chung-Jen Junior College of Nursing, Health Sciences and Management, 60077, Chiayi, Taiwan

    Wen-Lung Kuo

  6. Department of Pharmacy, Tajen University, 90741, Pingtung, Taiwan

    Li-Chai Chen & Jih-Jung Chen

  7. Department of Medical Research, China Medical University Hospital, 40447, Taichung, Taiwan

    Jih-Jung Chen

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  1. Li-Chai Chen
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  2. Zhi-Hong Wen
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  3. Ping-Jyun Sung
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  4. Chih-Wen Shu
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  5. Wen-Lung Kuo
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  6. Pei-Yu Chen
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  7. Jih-Jung Chen
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Correspondence to Jih-Jung Chen.

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Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2017, pp. 61–64.

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Chen, LC., Wen, ZH., Sung, PJ. et al. New Labdane-Type Diterpenoid and Cytotoxic Constituents of Hedychium coronarium . Chem Nat Compd 53, 72–76 (2017). https://doi.org/10.1007/s10600-017-1914-6

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  • DOI: https://doi.org/10.1007/s10600-017-1914-6

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