Two new isobenzofurans, 1-(3-hydroxypropanoyl)-2-methoxy-isobenzofuran-1(3H)-one (1) and 2-methoxy-1-prenyl-isobenzofuran-1(3H)-one (2), were isolated from the leaves of Yunnan local sun-cured tobacco. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their cytotoxicity. The results revealed that compound 1 exhibited cytotoxicity for NB4, A549, SHSY5Y, PC3, and MCF7 cells with IC50 values of 2.8, 5.4, 6.9, 3.8, and 4.9 μM, and compound 2 exhibited cytotoxicity for NB4, A549, SHSY5Y, PC3, and MCF7 cells with IC50 values of 6.6, 7.8, 9.4, 7.0, and 9.2 μM, respectively.
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Acknowledgment
This research was supported by the National Natural Science Foundation of China (Nos. 31360081, 21562049, 31400303), the Basic Research Foundation of Yunnan Province (Nos. 2013FB097, 2014FB163, 2015FB162), and the Basic Research Foundation of Yunnan Tobacco Industry Co. Ltd (2012JC01).
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Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2017, pp. 50–52.
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Shen, QP., Xu, XM., Zhang, FM. et al. Two New Isobenzofurans from Yunnan Local Sun-Cured Tobacco and Their Cytotoxicity. Chem Nat Compd 53, 59–62 (2017). https://doi.org/10.1007/s10600-017-1911-9
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DOI: https://doi.org/10.1007/s10600-017-1911-9