Mass spectrometry with electrospray ionization (ESI-MS) was used for the first time to study the formation of supramolecular complexes of glycyrrhetic acid (GLA) with benzimidazole (BMZ) derivatives (9-diethylaminoethyl-2,3-dihydroimidazo[1,2-a]benzimidazole dihydrochloride). ESI-MS spectra showed peaks for non-covalent complexes of GLA with BMZ that contained from 3 to 7 GLA molecules and one BMZ molecule (3:1, 4:1, 5:1, 6:1, and 7:1). Peaks for non-covalent complexes corresponding to ions containing one or two GLA molecules and one BMZ molecule (1:1 and 2:1) were not observed. Increasing the GLA mole fraction in the samples increased the peak intensities of the GLA–BMZ complexes. GLA self-assembly and GLA complexation with BMZ occurred simultaneously and were competitive.
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References
T. G. Tolstikova, A. G. Tolstikov, and G. A. Tolstikov, Vestn. Ross. Akad. Nauk, 77 (10), 867 (2007).
G. V. Obolentseva, V. I. Litvinenko, A. S. Ammosov, T. P. Popova, and A. M. Sampiev, Pharm. Chem. J., 33 (8), 427 (1999).
L. A. Yakovishin, N. I. Borisenko, M. I. Rudnev, E. V. Vetrova, and V. I. Grishkovets, Chem. Nat. Compd., 46, 49 (2010).
S. N. Borisenko, A. V. Lekaŕ, E. V. Vetrova, and N. I. Borisenko, Chem. Nat. Compd., 49, 969 (2013).
E. V. Vetrova, A. V. Lekarŕ, O. V. Filonova, S. N. Borisenko, E. V. Maksimenko, and N. I. Borisenko, Chem. Nat. Compd., 51, 500 (2015).
V. A. Vavilin, N. F. Salakhutdinov, Yu. I. Ragino, N. E. Polyakov, M. B. Taraban, T. V. Leshina, E. M. Stakhneva, V. V. Lyakhovich, Yu. P. Nikitin, and G. A. Tolstikov, Biochem. (Mosc.) Suppl. Ser. B: Biomed. Chem., 2 (4), 373 (2008).
I. V. Sorokina, T. G. Tolstikova, M. P. Dolgikh, E. E. Shul’ts, A. V. Dushkin, L. M. Karnatovskaya, E. N. Chabueva, and V. V. Boldyrev, Pharm. Chem. J., 36 (1), 11 (2002).
R. M. Kondratenko, L. A. Baltina, S. R. Mustafina, A. F. Ismagilova, F. S. Zarudii, V. A. Davydova, G. V. Bazekin, G. F. Suleimanova, and G. A. Tolstikov, Pharm. Chem. J., 37 (9), 485 (2003).
T. G. Tolstikova, I. V. Sorokina, I. L. Kovalenko, and A. G. Tolstikov, Dokl. Biol. Sci., 394, 31 (2004).
G. A. Tolstikov, L. A. Baltina, and N. G. Serdyuk, Pharm. Chem. J., 32 (8), 402 (1998).
B. A. Salakhutdinov, D. N. Dalimov, T. F. Aripov, I. I. Tukfatullina, R. Kh. Ziyatdinova, A. Zh. Dzhuraev, F. G. Kamaev, L. Yu. Izotova, B. T. Ibragimov, I. Mavridis, and P. Giastas, Chem. Nat. Compd., 38, 249 (2002).
O. V. Salomatina, E. B. Logashenko, D. V. Korchagina, N. F. Salakhutdinov, M. A. Zenkova, V. V. Vlasov, and G. A. Tolstikov, Dokl. Chem., 430 (2), 35 (2010).
S. N. Borisenko, A. V. Lekaŕ, E. V. Vetrova, O. V. Filonova, and N. I. Borisenko, Khim. Rastit. Syr’ya, No. 1, 89 (2015).
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The work was sponsored by the RF Ministry of Education and Science under State Task on Project No. 1895.
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Translated from Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2016, pp. 230–233.
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Vetrova, E.V., Borisenko, N.I. & Filonova, O.V. Mass Spectrometry of Self-Assembled Supramolecular Structures of Glycyrrhetic Acid with Benzimidazole. Chem Nat Compd 52, 262–265 (2016). https://doi.org/10.1007/s10600-016-1609-4
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DOI: https://doi.org/10.1007/s10600-016-1609-4