The formation of supramolecular complexes of glycyrrhetic acid (GLA) and levomycetin was detected and studied for the first time using electrospray-ionization mass spectrometry (ESI-MS). It was shown that the intermolecular complexes detected in the mass spectra were formed most effectively for a 1:1 host–guest ratio and less effectively for a 1:2 ratio. GLA aggregates (dimers and trimers) bound one or two levomycetin molecules and formed several singly and doubly charged cationic complexes. A comparison of the mass spectra of supramolecular complexes of glycyrrhizic acid (GA) and its aglycon (GLA) indicated that GLA self-aggregates and complexes with levomycetin formed more effectively than those of GA.
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The work was sponsored by the RF Ministry of Education and Science under the auspices of a State Task on Project No. 1895.
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Translated from Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2015, pp. 434–438.
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Vetrova, E.V., Lekar’, A.V., Filonova, O.V. et al. Mass Spectrometry of Self-Organizing Supramolecular Structures of Glycyrrhetic Acid and Levomycetin. Chem Nat Compd 51, 500–504 (2015). https://doi.org/10.1007/s10600-015-1324-6
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DOI: https://doi.org/10.1007/s10600-015-1324-6