Five acylation derivatives (1a–1e) were prepared by acylation of the bioactive natural product hypoxylin A (1) isolated from Halorosellinia oceanicum. Compounds 1a and 1b were epimers with the configuration inversion of C-10 in 1b. Hypoxylin A (1) and 1a–1e exhibited potent lethal activity toward the brine shrimp Artemia salina. Hypoxylin A (1) also showed cytotoxicity against tumor cell line A549 with an IC50 value of 5.6 μg/mL. The antibacterial activities of these compounds were also evaluated, and none of them were active.
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Acknowledgment
This work was supported by Guangdong Special Financial Fund of Innovative Development of Marine Economic Demonstration Project (GD2012-D01-001) and the Program for New Century Excellent Talents in University, Ministry of Education of China (No. NCET-11-0472).
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Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2015, pp. 776–779.
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Liu, QA., Shao, CL., Gu, YC. et al. Bioactive Hypoxylin a and its Five Acylates. Chem Nat Compd 51, 905–909 (2015). https://doi.org/10.1007/s10600-015-1445-y
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DOI: https://doi.org/10.1007/s10600-015-1445-y