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Manzamines: Marine Bioactive Heterocycles

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Marine Natural Products

Part of the book series: Topics in Heterocyclic Chemistry ((TOPICS,volume 58))

Abstract

After the first discovery of manzamine A from a marine sponge by Sakai and colleagues in 1986, its derivatives have attracted much attention among chemists and biologists due to their structural complexity and diverse biological activities. So far, more than 100 manzamine-related alkaloids have been identified, most of which have a fused 6-, 6-, 5-, 8-, and 13-membered ring system connected to a β-carboline as shown in manzamine A. In addition, a variety of bioactivities including cytotoxic, antimicrobial, antimalarial, anti-HIV, and insecticidal are reported. This review covers the recent reports of novel structures and biological activities of the manzamines.

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Author information

Authors and Affiliations

  1. Pharmaceutical Industries Research Division, Pharmacognosy Department, National Research Centre, Giza, Egypt

    Ahmed H. H. El-Desoky

  2. Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan

    Ahmed H. H. El-Desoky & Sachiko Tsukamoto

Authors
  1. Ahmed H. H. El-Desoky
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  2. Sachiko Tsukamoto
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Corresponding author

Correspondence to Sachiko Tsukamoto .

Editor information

Editors and Affiliations

  1. Okayama University, Okayama, Japan

    Hiromasa Kiyota

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El-Desoky, A.H.H., Tsukamoto, S. (2020). Manzamines: Marine Bioactive Heterocycles. In: Kiyota, H. (eds) Marine Natural Products. Topics in Heterocyclic Chemistry, vol 58. Springer, Singapore. https://doi.org/10.1007/7081_2020_42

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