Four new dialkylphosphonate derivatives 2–5 were prepared for the first time from the guaiane-type sesquiterpene lactone estafiatin (1), which was isolated from the aerial part of Achillea nobilis. Their structures were elucidated using PMR, 13C NMR, two-dimensional 1H–1H COSY, 13C–1H COLOC, and 31P–1H spectroscopy. The estafiatin phosphorylation reaction was highly chemo- and stereoselective. The antimicrobial activity of the prepared derivatives was studied.
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Translated from Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2014, pp. 734–736.
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Suleimen, E.M., Dzhalmakhanbetova, R.I., Pak, R.N. et al. Synthesis and Biological Activity of Estafiatin Phosphonate Derivatives. Chem Nat Compd 50, 846–849 (2014). https://doi.org/10.1007/s10600-014-1097-3
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DOI: https://doi.org/10.1007/s10600-014-1097-3