Phytochemical investigation of the ethyl acetate soluble extract from the rhizomes and roots of Smilax scobinicaulis resulted in the isolation of two new polymethoxylated flavones, namely 7,3′,5′-trihydroxy-5,6,4′-trimethoxyflavone (1) and 7-hydroxy-5,6,3′,4′,5′-pentamethoxyflavone (2), along with 17 known compounds (3–19) . Their structures were elucidated on the basis of spectral data. The in vitro cytotoxicity evaluation of the new compounds demonstrated that compound 1 showed weak activity to the tested MCF-7 and H520 cancer cell lines with IC50 values of 65.1 and 82.0 μM, respectively, while compound 2 was found to be inactive to both cell lines.
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Delectis Florae Reipublicae Popularis Sinicae Agendae Academiae Sinicae Edita. Flora Reipublicae Popolaris Sinicae, Vol. 15, Science Press, Beijing, 1978, p. 180.
J. Y. Liu, J. X. Fu, J. M. Gao, and M. H. Qiu, J. Northwest Sci-Tech. Univ. Agric. For., 30, 222 (2002).
C. L. Zhang, W. Zhu, Y. M. Cheng, and W. C. Li, Acta Bot. Boreal.–Occident. Sin., 23, 1973 (2003).
C. L. Zhang, W. C. Li, J. M. Gao, and J. X. Fu, J. Northwest Sci-Tech. Univ. Agric. For., 31, 163 (2003).
C. L. Zhang, J. M. Gao, and W. Zhu, Phytochem. Lett., 5, 49 (2010).
M. Iinuma, T. Tanaka, and S. Matsuura, Chem. Pharm. Bull., 32, 2296 (1984).
S. Galland, N. Mora, M. Abert-Vian, N. Rakotomanomana, and O. Dangles, J. Agric. Food Chem., 55, 7573 (2007).
C. Yenjai, S. Wanich, S. Pitchuanchom, and B. Sripanidkulchai, Arch. Pharm. Res., 32, 1179 (2009).
D. Zhen, Y. Jiang, K. Lou, Y. Chen, L. H. Xu, and L. Han, Chin. J. Med. Chem., 19, 375 (2009).
J. Li and D. Q. Yu, China J. Chin. Mater. Med., 36, 1458 (2011).
L. M. Guo, C. L. Shao, X. Liu, Y. C. Fang, Y. X. Wei, L. L. Song, Q. Q. Gu, W. M. Zhu, H. S. Guan, and C. Y. Wang, Chin. Trad. Herb. Drugs, 40, 1879 (2009).
L. H. Xiao, H. Y. Wang, S. J. Song, G. P. Zhang, H. X. Song, and S. X. Xu, J. Shenyang Pharm. Univ., 20, 181 (2003).
X. J. Gong, X. Zhou, Z. W. Cai, J. X. Zhang, and W. Zhou, China J. Chin. Mater. Med., 34, 177 (2009).
Q. An, C. J. Yang, Y. Song, K. Yu, Z. L. Xiong, and F. M. Li, Nat. Prod. Res. Dev., 20, 765 (2008).
K. N. Scott, J. Am. Chem. Soc., 94, 8564 (1972).
W. Yi, R. H. Cao, W. L. Peng, H. Wen, Q. Yan, B. H. Zhou, L. Ma, and H. C. Song, Eur. J. Med. Chem., 45, 639 (2010).
L. Dong, L. Li, Z. H. Liao, M. Chen, and M. Sun, Acta. Bot. Boreal. - Occident. Sin., 27, 2564 (2007).
W. J. Zheng, Y. Zhong, J. Y. Song, and P. Zhang, Chin. Trad. Herb. Drugs., 40, 859 (2009).
S. Li, R. Y. Chen, and D. Q. Yu, China J. Chin. Mater. Med., 32, 403 (2007).
F. Fu, X. Meng, S. Li, and L. Wu, Zhongcaoyao, 23, 344 (1992).
J. J. Liu and X. K. Liu, Chin. Trad. Herb. Drugs, 40, 186 (2009).
N. S. Bai, K. He, M. Poller, C. S. Lai, X. Shao, M. H. Pan, and C. T. Ho, Agric. Food Chem., 58, 5363 (2010).
K. R. Markham, B. Ternai, R. Stanley, H. Geiger, and T. J. Mabry, Tetrahedron, 34, 1389 (1978).
T. Mosmann, J. Immunol. Methods, 65, 55 (1983).
Acknowledgment
Financial support from the National Natural Science Foundation of China (30840063, 30770237) and Startup Foundation for Doctors of Northwest A&F University (01140506), as well as the Program for Changjiang Scholars and Innovative Research Team in University (IRT0749), is gratefully acknowledged.
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Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2014, pp. 225–227.
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Zhang, CL., Feng, SX., Wang, Q. et al. Flavonoids and Phenolic Compounds from Smilax scobinicaulis . Chem Nat Compd 50, 254–257 (2014). https://doi.org/10.1007/s10600-014-0925-9
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DOI: https://doi.org/10.1007/s10600-014-0925-9