Macrocycles with one and more ent-beyerane skeletons were prepared by the reaction of 16,19-dihydroxyent-beyerane with several dibasic carboxylic acid chlorides. The structures of the synthesized compounds, namely, the number of ent-beyerane skeletons in the macrocycle, depended on the length of the polymethylene chain in the acid chloride. The molecular structures of two of the synthesized macrocycles were establishedby x-ray crystal structures.
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Acknowledgment
The work was supported financially by RAS Presidium Programs Nos. 5 and 7; RAS DCMS Program No. 6; and the RFBR (Grant No. 10-03-00499-a).
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Translated from Khimiya Prirodnykh Soedinenii, No. 3,pp. 377–381, May–June, 2011.
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Garifullin, B.F., Strobykina, I.Y., Lodochnikova, O.A. et al. Synthesis of macrocycles with one and more ent-beyerane skeletons based on the diterpenoid isosteviol. Chem Nat Compd 47, 422–427 (2011). https://doi.org/10.1007/s10600-011-9949-6
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DOI: https://doi.org/10.1007/s10600-011-9949-6