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Synthesis and antiviralactivity of 2,3-seco-derivatives of betulonic acid

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Chemistry of Natural Compounds Aims and scope

A lupane 2,3-seco-aldehydoacid that was oxidized further to the 2,3-seco-diacid was synthesized by Beckmann fragmentation of the α-hydroxyoxime of betulonic acid. It was found that both 2,3-seco-derivatives were capable of suppresing reproduction of Herpes type 1 and flu A viruses (EC50 from 1.9 to 21.3 μM).

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Acknowledgment

The work was supported financially by RFBR Grant No. 08-03-00265-a.

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Authors and Affiliations

  1. Institute of Technical Chemistry, Ural Branch, Russian Academy of Sciences, 614013, Russia, Perm′, ul. Akad. Koroleva, 3

    I. A. Tolmacheva & V. V. Grishko

  2. Research Institute of Epidemiology and Microbiology, Ministry of Health, Republic of Belarus, 220114, Belarus, Minsk, ul. Filimonova, 23

    E. I. Boreko, O. V. Savinova & N. I. Pavlova

Authors
  1. I. A. Tolmacheva
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  2. V. V. Grishko
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  3. E. I. Boreko
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  4. O. V. Savinova
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  5. N. I. Pavlova
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Corresponding author

Correspondence to V. V. Grishko.

Additional information

Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 566–568, September–October 2009.

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Tolmacheva, I.A., Grishko, V.V., Boreko, E.I. et al. Synthesis and antiviralactivity of 2,3-seco-derivatives of betulonic acid. Chem Nat Compd 45, 673–676 (2009). https://doi.org/10.1007/s10600-009-9436-5

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  • DOI: https://doi.org/10.1007/s10600-009-9436-5

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