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Separation and identification of steroidal compounds with cytotoxic activity against human gastric cancer cell lines in vitro from the rhizomes of Paris polyphylla var. chinensis

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Abstract

A novel steroidal saponin, along with 12 known steroidal compounds, was isolated from the rhizomes of Paris polyphylla var. chinensis. Spectral data, including two-dimensional NMR, showed that the structure of the novel saponin was 3β,21-dihydroxypregnane-5-en-20S-(22,16)-lactone-1-O-α-L-rhamnopyranosyl(1→2)-[β-D-xylopyranosyl(1→3)]-β-D-glucopyranoside. The isolated steroidal compounds were evaluated for their cytotoxic activity on human gastric cancer cell line HepG2, SGC7901, BxPC3. Diosgenin-3-O-α-L-rhamnopyranosyl(1→2)[α-L-rabinofuranosyl(1→4)]-β-D-glucopyranoside exhibited the most potent cytotoxic activity among the isolated steroids.

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Authors and Affiliations

  1. Department of Pharmacognosy, Pharmaceutical College, Hebei Medical University, 050017, China

    Huang Yun, Zhan Wenhong, Wang Yongli & Zhao Ding

  2. Chinese Traditional Medicine College, Hebei Medical University, 050019, China

    Cui Lijian & Dou Yuhong

  3. China Pharmaceutical University, 210038, China

    Wang Qiang

Authors
  1. Huang Yun
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  2. Cui Lijian
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  3. Zhan Wenhong
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  4. Dou Yuhong
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  5. Wang Yongli
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  6. Wang Qiang
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  7. Zhao Ding
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Corresponding author

Correspondence to Huang Yun.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 6, pp. 556–560, November–December, 2007.

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Yun, H., Lijian, C., Wenhong, Z. et al. Separation and identification of steroidal compounds with cytotoxic activity against human gastric cancer cell lines in vitro from the rhizomes of Paris polyphylla var. chinensis . Chem Nat Compd 43, 672–677 (2007). https://doi.org/10.1007/s10600-007-0225-8

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  • DOI: https://doi.org/10.1007/s10600-007-0225-8

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