A simple procedure was developed for the synthesis of 2H-pyrido[3,4-c][1,2]benzoxazine-2,4(3H)-diones by the treatment of o-fluorophenyl-substituted 6-oxo-6H-1,2-oxazine-3-carboxylates with primary amines. The reaction proceeded according to the mechanism previously described for the formation of 3-(hydroxyimino)pyridine-2,6-diones followed by intramolecular nucleophilic substitution involving the hydroxyimino group to form the 1,2-oxazine ring.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2023, 59(1/2), 101–104
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Ivanov, D.S., Zaitseva, E.R., Smirnov, A.Y. et al. The synthesis of 2H-pyrido[3,4-c][1,2]benzoxazine-2,4(3H)-diones from 6-oxo-6H-1,2-oxazine-3-carboxylates. Chem Heterocycl Comp 59, 101–104 (2023). https://doi.org/10.1007/s10593-023-03168-0
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DOI: https://doi.org/10.1007/s10593-023-03168-0