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Chemistry of Heterocyclic Compounds

, Volume 54, Issue 2, pp 197–204 | Cite as

7-Alkylamino-6-nitrotetrazolo[1,5-a]pyrimidines as precursors of anomalous nucleosides and heterocycles with potential antiseptic activity

  • Konstantin V. Savateev
  • Victor V. Fedotov
  • Eugeny N. Ulomskiy
  • Vladimir L. Rusinov
Article

A method was developed for the synthesis of 7-alkylamino-5-methyl-6-nitrotetrazolo[1,5-a]pyrimidines from the readily available 5-methyl-6-nitrotetrazolo[1,5-a]pyrimidin-7(4H)-one by using a sequence of chlorodeoxygenation and amination reactions. The chlorinated intermediate formed along this route was isolated and characterized as 7-chloro-5-methyl-6-nitrotetrazolo[1,5-a]pyrimidine.

Keywords

tetrazolopyrimidines adenosine receptors azide-tetrazole tautomerism chlorodeoxygenation sepsis 

Notes

This work received financial support from the Russian Foundation for Basic Research (grant 16-33-00159 mol_a).

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Konstantin V. Savateev
    • 1
  • Victor V. Fedotov
    • 1
  • Eugeny N. Ulomskiy
    • 1
  • Vladimir L. Rusinov
    • 1
  1. 1.Ural Federal University named after the first President of Russia B. N. YeltsinYekaterinburgRussia

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