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7-Alkylamino-6-nitrotetrazolo[1,5-a]pyrimidines as precursors of anomalous nucleosides and heterocycles with potential antiseptic activity

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Chemistry of Heterocyclic Compounds Aims and scope

A method was developed for the synthesis of 7-alkylamino-5-methyl-6-nitrotetrazolo[1,5-a]pyrimidines from the readily available 5-methyl-6-nitrotetrazolo[1,5-a]pyrimidin-7(4H)-one by using a sequence of chlorodeoxygenation and amination reactions. The chlorinated intermediate formed along this route was isolated and characterized as 7-chloro-5-methyl-6-nitrotetrazolo[1,5-a]pyrimidine.

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This work received financial support from the Russian Foundation for Basic Research (grant 16-33-00159 mol_a).

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Authors and Affiliations

  1. Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St, Yekaterinburg, 620002, Russia

    Konstantin V. Savateev, Victor V. Fedotov, Eugeny N. Ulomskiy & Vladimir L. Rusinov

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  1. Konstantin V. Savateev
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  2. Victor V. Fedotov
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  3. Eugeny N. Ulomskiy
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  4. Vladimir L. Rusinov
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Correspondence to Konstantin V. Savateev.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2018, 54(2), 197–204

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Savateev, K.V., Fedotov, V.V., Ulomskiy, E.N. et al. 7-Alkylamino-6-nitrotetrazolo[1,5-a]pyrimidines as precursors of anomalous nucleosides and heterocycles with potential antiseptic activity. Chem Heterocycl Comp 54, 197–204 (2018). https://doi.org/10.1007/s10593-018-2254-6

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  • DOI: https://doi.org/10.1007/s10593-018-2254-6

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