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Reaction of 3-Aryl-2-Cyanoprop-2-ene- Thioamides With Bromonitromethane: A new Method for the Synthesis of Functionalized 1,2,4-Thiadiazoles

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Chemistry of Heterocyclic Compounds Aims and scope

The reaction of 3-aryl-2-cyanoprop-2-enethioamides with bromonitromethane leads to the products of oxidative dimerization, (2Е,2′E)-2,2′-(1,2,4-thiadiazole-3,5-diyl)bis(3-arylacrylonitriles). Their structure was confirmed by the counter synthesis through the oxidation of 3-aryl-2-cyanoprop-2-ene-thioamides by DMSO–HCl system.

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Authors and Affiliations

  1. “ChemEx” Laboratory, Vladimir Dal’East Ukrainian National University, 20-A/7 Molodyozhnyi Kv., Lugansk, 91034, Ukraine

    V. V. Dotsenko & S. G. Krivokolysko

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  1. V. V. Dotsenko
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  2. S. G. Krivokolysko
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Correspondence to V. V. Dotsenko.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 607-613, April, 2014.

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Dotsenko, V.V., Krivokolysko, S.G. Reaction of 3-Aryl-2-Cyanoprop-2-ene- Thioamides With Bromonitromethane: A new Method for the Synthesis of Functionalized 1,2,4-Thiadiazoles. Chem Heterocycl Comp 50, 557–563 (2014). https://doi.org/10.1007/s10593-014-1507-2

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  • DOI: https://doi.org/10.1007/s10593-014-1507-2

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