The aminomethylation of 6-amino-4-aryl-2-oxo-1,2-dihydropyridine-3,5-dicarbonitriles by treatment with primary amines and an excess of formaldehyde resulted in the formation of 3-R-8-aryl-6-oxo-1,3,4,6-tetrahydro-2Н-pyrido[1,2-а][1,3,5]triazine-7,9-dicarbonitriles. The structure of 6-oxo-3,8-di-phenyl-1,3,4,6-tetrahydro-2Н-pyrido[1,2-а][1,3,5]triazine-7,9-dicarbonitrile was investigated by X-ray structural analysis.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 52-58, 2014.
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Khrustaleva, A.N., Frolov, K.A., Dotsenko, V.V. et al. Synthesis of Pyrido[1,2-a][1,3,5]Triazine Derivatives by Aminomethylation of 6-Amino-4-Aryl-2-Oxo-1,2-Dihydropyridine-3,5-Dicarbonitriles. Chem Heterocycl Comp 50, 46–52 (2014). https://doi.org/10.1007/s10593-014-1447-x
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DOI: https://doi.org/10.1007/s10593-014-1447-x