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Polyfunctional Pyrazoles. 8*. Synthesis of 6-Alkyl-2-Aryl-2H-Pyrazolo[4,3-d]Pyrimidine-5,7(4H,6H)-Diones based on Ethyl 1-Aryl-4-Isocyanatopyrazole-3-Carboxylates

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Chemistry of Heterocyclic Compounds Aims and scope

A method for the preparation of 6-alkyl-2-aryl-2H-pyrazolo[4,3-d]pyrimidine-5,7(4H,6H)-diones in reaction of ethyl 1-aryl-4-isocyanatopyrazole-3-carboxylates with aliphatic amines followed by cyclization of the obtained 4-ureidopyrazole-3-carboxylic acid esters in the presence of bases is proposed.

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Authors and Affiliations

  1. Bukovinsk State Medical University, 2 Teatral’naya Sq., Chernovtsy, 58002, Ukraine

    M. K. Bratenko & M. M. Barus

  2. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv, 02094, Ukraine

    M. V. Vovk

Authors
  1. M. K. Bratenko
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  2. M. M. Barus
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  3. M. V. Vovk
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Correspondence to M. K. Bratenko.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1443-1450, September, 2013.

*For Communication 7, see [1].

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Bratenko, M.K., Barus, M.M. & Vovk, M.V. Polyfunctional Pyrazoles. 8*. Synthesis of 6-Alkyl-2-Aryl-2H-Pyrazolo[4,3-d]Pyrimidine-5,7(4H,6H)-Diones based on Ethyl 1-Aryl-4-Isocyanatopyrazole-3-Carboxylates. Chem Heterocycl Comp 49, 1345–1351 (2013). https://doi.org/10.1007/s10593-013-1383-1

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  • DOI: https://doi.org/10.1007/s10593-013-1383-1

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