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Facile one-pot synthesis of the pyrazolo[1,5-a]pyrazine scaffold

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Chemistry of Heterocyclic Compounds Aims and scope

A series of novel pyrazolo[1,5-a]pyrazine derivatives has been synthesized using a facile one-pot three-step protocol starting from pyrazole-3-carboxylic acids. The process occurs via amide formation with consequent pyrazine ring closure, hydrolysis, and dehydration. 7-Hydroxy-6,7-dihydropyrazolo[1,5-a]-pyrazin-4(5H)-one and 7-methoxy-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one have been isolated as intermediate compounds.

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Authors and Affiliations

  1. National University of Pharmacy, 53 Pushkinska St., Kharkiv, 61002, Ukraine

    O. V. Zaremba, S. S. Kovalenko, O. G. Drushlyak, O. Yu. Grevtsov & S. M. Kovalenko

  2. Scientific-Technological Complex “Institute of Monocrystals”, National Academy of Science of Ukraine, 60 Lenin Ave., Kharkiv, 61001, Ukraine

    N. Yu. Gorobets

Authors
  1. O. V. Zaremba
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  2. N. Yu. Gorobets
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  3. S. S. Kovalenko
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  4. O. G. Drushlyak
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  5. O. Yu. Grevtsov
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  6. S. M. Kovalenko
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Correspondence to O. G. Drushlyak.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 980-986, June, 2013.

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Zaremba, O.V., Gorobets, N.Y., Kovalenko, S.S. et al. Facile one-pot synthesis of the pyrazolo[1,5-a]pyrazine scaffold. Chem Heterocycl Comp 49, 915–921 (2013). https://doi.org/10.1007/s10593-013-1326-x

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  • DOI: https://doi.org/10.1007/s10593-013-1326-x

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