Abstract
Dialkylaminoalkylamides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids have been obtained as potential antiviral agents. The special features of the spatial structure of one example of the synthesized compounds have been studied. Results are given of the investigation of cytotoxicity and antiviral activity in relation to type 1 herpes virus and coronavirus.
Article PDF
Similar content being viewed by others
References
I. V. Ukrainets, E. V. Mospanova, N. L. Bereznyakova, and O. I. Naboka, Khim. Geterotsikl. Soedin., 1808 (2007). [Chem. Heterocycl. Comp., 43, 1532 (2007)].
A. Simmons, Herpes, 8, 60 (2001).
M. M. Saksena, H. Wakisaka, B. Tijono, R. A. Boadle, F. Rixon, H. Takahashi, and A. L. Cunninghman, J. Virol., 80, 3592 (2006).
K. Kardos and M. McErlean, Am. J. Emerg. Med., 24, 885 (2006).
D. T. Fleming, P. Leone, D. Esposito, C. K. Heitman, S. Justus, S. Chin, and K. H. Fife, Sex. Transm. Dis., 33, 416 (2006).
E. Alemparte-Pardavila, N. Pineiro-Sande, E. Merayo Macias, J. L. Martinez-Melgar, Med. Clin. (Barc.), 127, 400 (2006).
A. I. Ibrahim, M. T. Obeid, M. J. Jouma, K. Roemer, N. Mueller-Lantzsch, and B. C. Gartner, J. Clin. Microbiol., 43, 4172 (2005).
D. M. Parkin, Int. J. Cancer, 118, 3030 (2006).
F. Ginanneschi, D. Donati, D. Moschettini, F. Dominici, C. Cermelli, and A. Rossi, Clin. Neurol. Neurosurg., 109, 272 (2007).
S. S. Chow, M. E. Craig, C. F. Jacques, B. Hall, J. Catteau, S. C. Munro, G. M. Scott, C. Camaris, C. J. McIver, and W. D. Rawlinson, J. Med. Virol., 78, 747, (2006).
S. Yoshinari, S. Hamano, M. Minamitani, M. Tanaka, and Y. Eto, Pediatr. Neurol., 36, 13 (2007).
A. B. Farris and R. L. Kradin, Virchows Arch., 449, 726 (2006).
A. Kleemann and J. Engel, Pharmaceutical Substances: Syntheses, Patents, Applications, Thieme Medical, Stuttgart (2001).
http://www.ibmc.msk.ru/PASS/ or http://ibmc.p450.ru/PASS/
H.-B. Burgi and J. D. Dunitz, Structure Correlation, Vol. 2, VCH, Weinheim (1994), p. 741.
I. V. Ukrainets, N. L. Bereznyakova, G. P. Petyunin, I. A. Tugaibei, V. B. Rybakov, V. V. Chernyshev, and A. V. Turov, Khim. Geterotsikl. Soedin., 864 (2007). [Chem. Heterocycl. Comp., 43, 864 (2007)].
N. Thorup and O. Simonsen, Acta Crystallogr. C41, 472 (1985).
C. Plug, B. Wallfisch, H. G. Andersen, P. V. Bernhardt, L.-J. Baker, G. R. Clark, Ming Wah Wong, and C. Wentrup, J. Chem. Soc., Perkin Trans. 2, 2096 (2000).
Yu. V. Zefirov, Kristallografiya, 42, 936 (1997).
G. M. Sheldrick, SHELXTL PLUS, PC Version. A System of Computer Programs for the Determination of Crystal Structure from X-ray Diffraction Data. Rev. 5.1 (1998).
Author information
Authors and Affiliations
Corresponding author
Additional information
__________
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 61–77, January, 2008.
Rights and permissions
About this article
Cite this article
Ukrainets, I.V., Bereznyakova, N.L. & Turaibei, I.A. 4-Hydroxy-2-quinolones 139. Synthesis, structure, and antiviral activity of N-R-amides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids. Chem Heterocycl Comp 44, 50–63 (2008). https://doi.org/10.1007/s10593-008-0012-x
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10593-008-0012-x