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Synthesis and Antiviral Activity of Novel Thieno[2,3-d]pyrimidine Hydrazones and Their C-Nucleosides

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Abstract

A hydrazinylthienopyrimidine derivative reacted with a number of monosaccharides in the presence of a catalytic amount of acetic acid giving the corresponding sugar hydrazones, that undergo oxidative cyclization under the action of ferric chloride with formation of triazolo derivatives. Structures of the products have been elucidated from IR, 1H, and 13C NMR data. Antiviral activity of the newly synthesized compounds is tested against influenza virus H5N1.

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Authors and Affiliations

  1. Photochemistry Department, National Research Centre, Dokki, Cairo, 12622, Egypt

    R. R. Khattab, K. M. Abuzeid & N. A. Hassan

  2. Chemistry Department, Faculty of Science, University of Suez, Suez, Egypt

    A. A. Hassan

  3. Pharmaceutical Science Department, College of Pharmacy, Shaqra University, Riyadh, Saudi Arabia

    A. A. Hassan & N. A. Hassan

  4. Center of Scientific Excellence for Influenza Virus, National Research Centre, Dokki, Cairo, 12311, Egypt

    O. M. Kutkat

Authors
  1. R. R. Khattab
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  2. A. A. Hassan
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  3. O. M. Kutkat
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  4. K. M. Abuzeid
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  5. N. A. Hassan
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Correspondence to R. R. Khattab or N. A. Hassan.

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No conflict of interest was declared by the authors.

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Khattab, R.R., Hassan, A.A., Kutkat, O.M. et al. Synthesis and Antiviral Activity of Novel Thieno[2,3-d]pyrimidine Hydrazones and Their C-Nucleosides. Russ J Gen Chem 89, 1707–1717 (2019). https://doi.org/10.1134/S1070363219080267

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  • DOI: https://doi.org/10.1134/S1070363219080267

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