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Synthesis of azinylthioureas and their heterocyclization using α-chloroacetoacetic ester

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Treatment of aminopyrimidines with a mixture of PhCOCl and NH4SCN and subsequent debenzoylation of the N-benzoyl-N′-(4,6-substituted pyrimidin-2-yl)thioureas obtained gave pyrimidinyl-2-thioureas. The heterocyclization of the azinyl-2-thioureas with α-chloroacetoacetic ester gave ethyl 2-(4,6-substituted azin-2-yl)aminothiazole-5-carboxylates.

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Authors and Affiliations

  1. Armenian Agricultural Academy, Yerevan, 375009

    V. V. Dovlatyan, K. A. Eliazyan, E. A. Ghazaryan & A. P. Yengoyan

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  1. V. V. Dovlatyan
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  2. K. A. Eliazyan
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  3. E. A. Ghazaryan
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  4. A. P. Yengoyan
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 437–440, March, 2006.

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Dovlatyan, V.V., Eliazyan, K.A., Ghazaryan, E.A. et al. Synthesis of azinylthioureas and their heterocyclization using α-chloroacetoacetic ester. Chem Heterocycl Compd 42, 389–391 (2006). https://doi.org/10.1007/s10593-006-0097-z

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  • DOI: https://doi.org/10.1007/s10593-006-0097-z

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