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Synthesis of some new biologically active coumarin derivatives

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The reaction of 4-hydroxycoumarin in toluene with a variety of aromatic binucleophilic compounds has been studied. 3-(Dimethylaminomethylene)chromane-2,4-dione was used as a key intermediate for the preparation of bis[N-(4-oxocoumarinylmethylene)]-1,4-diamines. Alternative synthetic procedures and antibacterial activity data of some of the new compounds are given.

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Authors and Affiliations

  1. Institut National de Recherche et d’Analyse physicochimique, Technopole de Sidi Thabet, 2020, Tunisie

    N. Hamdi & H. Zarrouk

  2. Dpto. Quimica Fisica, Bioquimica y Quimica Inorganica, Universidad de Almeria, Almeria, Spain

    C. Lidrissi, M. Saoud & A. Romerosa Nievas

Authors
  1. N. Hamdi
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  2. C. Lidrissi
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  3. M. Saoud
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  4. A. Romerosa Nievas
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  5. H. Zarrouk
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Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 361–366, March, 2006.

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Hamdi, N., Lidrissi, C., Saoud, M. et al. Synthesis of some new biologically active coumarin derivatives. Chem Heterocycl Compd 42, 320–325 (2006). https://doi.org/10.1007/s10593-006-0088-0

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  • DOI: https://doi.org/10.1007/s10593-006-0088-0

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