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Hybrid Ethers of 8-Hydroxyquinoline and Coumarin, 1-Azacoumarin Moieties: Synthesis, Spectral Studies and Biological Evaluation

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Abstract

Methylene bridged ethers obtained from the reaction of 8-hydroxy quinoline and 4-bromomethyl coumarins and 1-aza-coumarins have been found to exhibit a broad spectrum of anti-microbial activity against both gram positive and gram negative bacterial strains. Modeling studies predict higher hydrophilicities for the compounds which are indicated by their lower LogP values. Gel electrophoresis has revealed their ability to cleave E. coli DNA. Structures have been confirmed by spectroscopic and single crystal X-ray diffraction studies.

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Acknowledgements

The authors thank NMR Research Center, Indian Institute of Science (IISc), Bangalore and University Sophisticated Instrumentation Center (USIC), Dharwad for spectral analysis. Authors acknowledge UGC for providing RFSMS scholarship.

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  1. Department of Studies in Chemistry, Karnatak University, Dharwad, Karnataka State, 580003, India

    Hrishikesh Mohan Revankar & Manohar Vasantrao Kulkarni

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  1. Hrishikesh Mohan Revankar
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  2. Manohar Vasantrao Kulkarni
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Correspondence to Manohar Vasantrao Kulkarni.

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Revankar, H.M., Kulkarni, M.V. Hybrid Ethers of 8-Hydroxyquinoline and Coumarin, 1-Azacoumarin Moieties: Synthesis, Spectral Studies and Biological Evaluation. Proc. Natl. Acad. Sci., India, Sect. A Phys. Sci. 88, 1–8 (2018). https://doi.org/10.1007/s40010-016-0337-2

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