Abstract
The mechanism of formation of 4,6,6-trimethyl-2-oxo-1,2,5,6-tetrahydropyridine-3-carbonitrile from 4-hydroxy-4-methylpentan-2-one and cyanoacetamide in the presence of ammonium acetate has been studied by the AM1 method. It was found that, under the reaction conditions, the amide is readily converted to an iminol tautomeric form which takes part in subsequent reaction. It was shown that the reaction is a cascade process forming two intermediates. The final product 4,6,6-trimethyl-2-oxo-1,2,5,6-tetrahydropyridine-3-carbonitrile is formed from the product of a Knoevenagel condensation via an intramolecular nucleophilic substitution mechanism. On the basis of the activation energies obtained it can be deduced that the limiting stage is the deprotonation process of the cyanoacetiminol.
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References
T. Eicher and S. Hauptmann, The Chemistry of Heterocycles. Structure, Reactions, Syntheses, and Applications, Wiley-VCH, Weinheim (2003), 572. pp.
R. B. Silverman, The Organic Chemistry of Drug Design and Drug Action, Elsevier, Amsterdam (2004), 550. pp.
N. Veretennikova, A. Skorova, D. Jansone, E. Lukevics, L. Leite, and G. Melikyan, Drugs of the Future, 27,Supplement A, 457 (2002).
V. I. Minkin, B. Y. Simkin, and R. M. Miniaev, Quantum Chemistry of Organic Compounds: Mechanisms and Reactions, Springer-Verlag, Berlin (1990), 270. pp.
D. Jansone, M. Fleisher, G. Andreeva, L. Leite, and E. Lukevics, Khim. Geterotsikl. Soedin., 1863 (2005).
M. J. S. Dewar, E. G. Zoebisch, E. F. Healy, and J. J. P. Stewart, J. Am. Chem. Soc., 107, 3902 (1985).
K. M. Merz, R. Hoffmann, and M. J. S. Dewar, J. Am. Chem. Soc., 111, 5636 (1989).
R. Rajamani and J. Gao, J. Am. Chem. Soc., 125, 12768 (2003).
A. Sygula, J. Chem. Res. (S), 56 (1989).
F. H. Allen, O. Kennard, and D. G. Watson, J. Chem. Soc., Perkin Trans. 2, No. 12, S1 (1987).
C. K. Ingold, Structure and Mechanism in Organic Chemistry, Cornell Univ. Press, Ithaca (1969), chap. 9.
G. Jones, in: A. C. Cope (editor), Organic Reactions, Wiley & Sons, Inc., New York, London, Sydney, 1967, Vol. 15, p. 204.
J. J. P. Stewart, MOPAC, Version 6, QCPE N 455, Bloomington (1984).
ChemCraft: http://chemcraft.boom.ru.
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Dedicated to Professor L. I. Belen’kii with gratitude and deep respect.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 209–216, February, 2006.
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Fleisher, M., Jansone, D., Leite, L. et al. Quantum-chemical investigation of the mechanism of cyclocondensation of 4-hydroxy-4-methylpentan-2-one with cyanoacetamide using the AM1 method. Chem Heterocycl Compd 42, 184–190 (2006). https://doi.org/10.1007/s10593-006-0069-3
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DOI: https://doi.org/10.1007/s10593-006-0069-3