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Synthesis of cytotoxic derivatives of 2-oxo-1-azetidinylacetamide

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

New derivatives of 2-oxo-1-azetidinylacetamide have been synthesized by the four-component condensation of β-amino acids with aldehydes and isonitriles. Study of their cytotoxic activity in vitro revealed a cytotoxic effect of individual compounds in relation to cancer cells of human fibrosarcoma, mouse hepatoma, and mouse neuroblastoma.

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Authors and Affiliations

  1. Latvian Institute of Organic Synthesis, Riga, LV-1006

    G. Veinberg, K. Dikovskaya, M. Vorona, I. Turovskis, I. Shestakova, I. Kanepe & E. Lukevics

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  1. G. Veinberg
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  2. K. Dikovskaya
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  3. M. Vorona
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  4. I. Turovskis
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  5. I. Shestakova
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  6. I. Kanepe
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  7. E. Lukevics
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 107–112, January, 2005.

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Veinberg, G., Dikovskaya, K., Vorona, M. et al. Synthesis of cytotoxic derivatives of 2-oxo-1-azetidinylacetamide. Chem Heterocycl Compd 41, 93–97 (2005). https://doi.org/10.1007/s10593-005-0113-8

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  • DOI: https://doi.org/10.1007/s10593-005-0113-8

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