Abstract
2-Hetaryl-3-oxo-4-phthalimidobutyronitriles (and pentanonitriles) were obtained with high yields by C-acylation of hetarylacetonitriles with N-phthaloylglycine and α-alanine chlorides respectively under the conditions of base catalysis. Hydrazinolysis of the phthaloyl protection in these compounds leads to the formation of 5-amino-4-hetaryl-2,3-dihydro-1H-3-pyrrolones.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1783–1790, December, 2004.
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Tverdokhlebov, A.V., Lyashenko, A.B., Volovenko, Y.M. et al. Synthesis of 5-amino-4-hetaryl-2,3-dihydro-1h-3-pyrrolones. Chem Heterocycl Compd 40, 1536–1542 (2004). https://doi.org/10.1007/s10593-005-0095-6
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DOI: https://doi.org/10.1007/s10593-005-0095-6