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The Mechanism Underlying the Regulation of Long Non-coding RNA MEG3 in Cerebral Ischemic Stroke

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Abstract

Cerebral ischemic stroke is one of the leading causes of morbidity and mortality worldwide, and rapidly increasing annually with no more effective therapeutic measures. Thus, the novel diagnostic and prognostic biomarkers are urgent to be identified for prevention and therapy of ischemic stroke. Recently, long noncoding RNAs (lncRNAs), a major family of noncoding RNAs with more than 200 nucleotides, have been considered as new targets for modulating pathological process of ischemic stroke. In this review, we summarized that the lncRNA-maternally expressed gene 3 (MEG3) played a critical role in promotion of neuronal cell death and inhibition of angiogenesis in response to hypoxia or ischemia condition, and further described the challenge of overcrossing blood–brain barrier (BBB) and determination of optimal carrier for delivering lncRNA’ drugs into the specific brain regions. In brief, MEG3 will be a potential diagnostic biomarker and drug target in treatment and therapy of ischemic stroke in the future.

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References

  • Ahmad I, Valverde A, Ahmad F, Naqvi AR (2020) Long noncoding RNA in myeloid and lymphoid cell differentiation, polarization and function. Cells 9(2):269

    Article  CAS  Google Scholar 

  • Alishahi M, Ghaedrahmati F, Kolagar TA, Winlow W, Nikkar N, Farzaneh M, Khoshnam SE (2019) Long non-coding RNAs and cell death following ischemic stroke. Metab Brain Dis 34:1243–1251

    Article  CAS  Google Scholar 

  • Bao MH, Szeto V, Yang BB, Zhu SZ, Sun HS, Feng ZP (2018) Long non-coding RNAs in ischemic stroke. Cell Death Dis 9:281

    Article  Google Scholar 

  • Bejot Y, Daubail B, Giroud M (2016) Epidemiology of stroke and transient ischemic attacks: Current knowledge and perspectives. Rev Neurol (paris) 172:59–68

    Article  CAS  Google Scholar 

  • Benetatos L, Vartholomatos G, Hatzimichael E (2011) MEG3 imprinted gene contribution in tumorigenesis. Int J Cancer 129:773–779

    Article  CAS  Google Scholar 

  • Blokhin I, Khorkova O, Hsiao J, Wahlestedt C (2018) Developments in lncRNA drug discovery: where are we heading? Expert Opin Drug Discov 13:837–849

    Article  CAS  Google Scholar 

  • Catanese L, Tarsia J, Fisher M (2017) Acute ischemic stroke therapy overview. Circ Res 120:541–558

    Article  CAS  Google Scholar 

  • Chen LL (2016) Linking long noncoding RNA localization and function. Trends Biochem Sci 41:761–772

    Article  CAS  Google Scholar 

  • Chen J, Zhang W, Wu YQ, Chen H, Zhao JF (2019) LncRNA SNHG1 inhibits neuronal apoptosis in cerebral infarction rats through PI3K/Akt signaling pathway. Eur Rev Med Pharmacol Sci 23:5366–5373

    CAS  Google Scholar 

  • da Rocha ST, Edwards CA, Ito M, Ogata T, Ferguson-Smith AC (2008) Genomic imprinting at the mammalian Dlk1-Dio3 domain. Trends Genet (TIG) 24:306–316

    Article  Google Scholar 

  • Datta A, Sarmah D, Mounica L, Kaur H, Kesharwani R, Verma G, Veeresh P, Kotian V, Kalia K, Borah A et al (2020) Cell death pathways in ischemic stroke and targeted pharmacotherapy. Transl Stroke Res 11(6):1185–1202

    Article  Google Scholar 

  • Deng D, Liang H (2020) Silencing MEG3 protects PC12 cells from hypoxic injury by targeting miR-21. Artif Cells Nanomed Biotechnol 48:610–619

    Article  CAS  Google Scholar 

  • Deng QW, Li S, Wang H, Sun HL, Zuo L, Gu ZT, Lu G, Sun CZ, Zhang HQ, Yan FL (2018) Differential long noncoding RNA expressions in peripheral blood mononuclear cells for detection of acute ischemic stroke. Clin Sci (lond Engl 1979) 132:1597–1614

    Article  CAS  Google Scholar 

  • Deng W, Fan C, Shen R, Wu Y, Du R, Teng J (2020) Long noncoding MIAT acting as a ceRNA to sponge microRNA-204-5p to participate in cerebral microvascular endothelial cell injury after cerebral ischemia through regulating HMGB1. J Cell Physiol 235:4571–4586

    Article  CAS  Google Scholar 

  • Diederichs S (2014) The four dimensions of noncoding RNA conservation. Trends Genet (TIG) 30:121–123

    Article  CAS  Google Scholar 

  • Disdier C, Stonestreet BS (2020) Hypoxic-ischemic-related cerebrovascular changes and potential therapeutic strategies in the neonatal brain. J Neurosci Res 98:1468–1484

    Article  CAS  Google Scholar 

  • Dong Z, Pan K, Pan J, Peng Q, Wang Y (2018) The possibility and molecular mechanisms of cell pyroptosis after cerebral ischemia. Neurosci Bull 34:1131–1136

    Article  Google Scholar 

  • Esteller M (2011) Non-coding RNAs in human disease. Nat Rev Genet 12:861–874

    Article  CAS  Google Scholar 

  • Fan B, Pan W, Wang X, Wei M, He A, Zhao A, Chopp M, Zhang ZG, Liu XS (2020) Long noncoding RNA mediates stroke-induced neurogenesis. Stem Cells 38(8):973–985

    Article  CAS  Google Scholar 

  • Fatemi RP, Velmeshev D, Faghihi MA (2014) De-repressing LncRNA-targeted genes to upregulate gene expression: focus on small molecule therapeutics. Mol Ther Nucleic Acids 3:e196

    Article  Google Scholar 

  • Granger DN, Kvietys PR (2015) Reperfusion injury and reactive oxygen species: the evolution of a concept. Redox Biol 6:524–551

    Article  CAS  Google Scholar 

  • Han L, Dong Z, Liu N, Xie F, Wang N (2017) Maternally expressed gene 3 (MEG3) enhances PC12 cell hypoxia injury by targeting MiR-147. Cell Physiol Biochem 43:2457–2469

    Article  CAS  Google Scholar 

  • Hangauer MJ, Vaughn IW, McManus MT (2013) Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs. PLoS Genet 9:e1003569

    Article  CAS  Google Scholar 

  • Hashemian F, Ghafouri-Fard S, Arsang-Jang S, Mirzajani S, Fallah H, Mehvari Habibabadi J, Sayad A, Taheri M (2019) Epilepsy is associated with dysregulation of long non-coding RNAs in the peripheral blood. Front Mol Biosci 6:113

    Article  CAS  Google Scholar 

  • He W, Wei D, Cai D, Chen S, Li S, Chen W (2018) Altered long non-coding RNA transcriptomic profiles in ischemic stroke. Hum Gene Ther 29:719–732

    Article  CAS  Google Scholar 

  • Hribljan V, Lisjak D, Petrović DJ, Mitrečić D (2019) Necroptosis is one of the modalities of cell death accompanying ischemic brain stroke: from pathogenesis to therapeutic possibilities. Croat Med J 60:121–126

    Article  CAS  Google Scholar 

  • Jeppesen DK, Fenix AM, Franklin JL, Higginbotham JN, Zhang Q, Zimmerman LJ, Liebler DC, Ping J, Liu Q, Evans R et al (2019) Reassessment of exosome composition. Cell 177:428-445.e418

    Article  CAS  Google Scholar 

  • Johnson R (2012) Long non-coding RNAs in Huntington’s disease neurodegeneration. Neurobiol Dis 46:245–254

    Article  CAS  Google Scholar 

  • Johnsson P, Lipovich L, Grandér D, Morris KV (2014) Evolutionary conservation of long non-coding RNAs; sequence, structure, function. Biochem Biophys Acta 1840:1063–1071

    Article  CAS  Google Scholar 

  • Kapranov P, Cheng J, Dike S, Nix DA, Duttagupta R, Willingham AT, Stadler PF, Hertel J, Hackermüller J, Hofacker IL et al (2007) RNA maps reveal new RNA classes and a possible function for pervasive transcription. Science (new York, NY) 316:1484–1488

    Article  CAS  Google Scholar 

  • Kim SS, Rait A, Garrido-Sanabria ER, Pirollo KF, Harford JB, Chang EH (2018) Nanotherapeutics for gene modulation that prevents apoptosis in the brain and fatal neuroinflammation. Mol Ther 26:84–94

    Article  CAS  Google Scholar 

  • Kopp F, Mendell JT (2018) Functional classification and experimental dissection of long noncoding RNAs. Cell 172:393–407

    Article  CAS  Google Scholar 

  • Kozlov MM, Campelo F, Liska N, Chernomordik LV, Marrink SJ, McMahon HT (2014) Mechanisms shaping cell membranes. Curr Opin Cell Biol 29:53–60

    Article  CAS  Google Scholar 

  • Kumar MM, Goyal R (2017) LncRNA as a therapeutic target for angiogenesis. Curr Top Med Chem 17:1750–1757

    Article  CAS  Google Scholar 

  • Liang J, Wang Q, Li JQ, Guo T, Yu D (2020) Long non-coding RNA MEG3 promotes cerebral ischemia-reperfusion injury through increasing pyroptosis by targeting miR-485/AIM2 axis. Exp Neurol 325:113139

    Article  CAS  Google Scholar 

  • Lim W, Kim HS (2019) Exosomes as therapeutic vehicles for cancer. Tissue Eng Regen Med 16:213–223

    Article  CAS  Google Scholar 

  • Ling H (2016) Non-coding RNAs: therapeutic strategies and delivery systems. Adv Exp Med Biol 937:229–237

    Article  CAS  Google Scholar 

  • Liu X, Hou L, Huang W, Gao Y, Lv X, Tang J (2016) The mechanism of long non-coding RNA MEG3 for neurons apoptosis caused by hypoxia: mediated by miR-181b-12/15-LOX signaling pathway. Front Cell Neurosci 10:201

    Article  Google Scholar 

  • Liu J, Li Q, Zhang KS, Hu B, Niu X, Zhou SM, Li SG, Luo YP, Wang Y, Deng ZF (2017) Downregulation of the long non-coding RNA Meg3 promotes angiogenesis after ischemic brain injury by activating notch signaling. Mol Neurobiol 54:8179–8190

    Article  CAS  Google Scholar 

  • Liu B, Xu T, Meng Y (2020) IncRNA NEAT1 aggravates cerebral ischemia/reperfusion injury by sponging miR-874-3p. J Biol Regul Homeostatic Agents. https://doi.org/10.23812/20-38A

  • Long FQ, Su QJ, Zhou JX, Wang DS, Li PX, Zeng CS, Cai Y (2018) LncRNA SNHG12 ameliorates brain microvascular endothelial cell injury by targeting miR-199a. Neural Regen Res 13:1919–1926

    Article  CAS  Google Scholar 

  • Lu Y, Chen L, Li L, Cao Y (2020) Exosomes derived from brain metastatic breast cancer cells destroy the blood-brain barrier by carrying lncRNA GS1-600G8.5. BioMed Res Int 2020:7461727

    Article  Google Scholar 

  • Luo HC, Yi TZ, Huang FG, Wei Y, Luo XP, Luo QS (2020a) Role of long noncoding RNA MEG3/MiR-378/GRB2 axis in neuronal autophagy and neurological functional impairment in ischemic stroke. J Biol Chem 295(41):14125–14139

    Article  CAS  Google Scholar 

  • Luo R, Jin H, Li L, Hu YX, Xiao F (2020b) Long noncoding RNA MEG3 inhibits apoptosis of retinal pigment epithelium cells induced by high glucose via the miR-93/Nrf2 axis. Am J Pathol 190(9):1813–1822

    Article  CAS  Google Scholar 

  • Mattick JS, Makunin IV (2006) Non-coding RNA. Hum Mol Genet 15:R17–R29

    Article  CAS  Google Scholar 

  • Mercer TR, Mattick JS (2013) Structure and function of long noncoding RNAs in epigenetic regulation. Nat Struct Mol Biol 20:300–307

    Article  CAS  Google Scholar 

  • Miyoshi N, Wagatsuma H, Wakana S, Shiroishi T, Nomura M, Aisaka K, Kohda T, Surani MA, Kaneko-Ishino T, Ishino F (2000) Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q. Genes Cells 5:211–220

    Article  CAS  Google Scholar 

  • Mokin M, Ansari SA, McTaggart RA, Bulsara KR, Goyal M, Chen M, Fraser JF (2019) Indications for thrombectomy in acute ischemic stroke from emergent large vessel occlusion (ELVO): report of the SNIS Standards and Guidelines Committee. J Neurointervent Surg 11:215–220

    Article  Google Scholar 

  • Nitta T, Hata M, Gotoh S, Seo Y, Sasaki H, Hashimoto N, Furuse M, Tsukita S (2003) Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol 161:653–660

    Article  CAS  Google Scholar 

  • Peng Z, Liu C, Wu M (2018) New insights into long noncoding RNAs and their roles in glioma. Mol Cancer 17:61

    Article  Google Scholar 

  • Perry RB, Ulitsky I (2016) The functions of long noncoding RNAs in development and stem cells. Development (camb, Engl) 143:3882–3894

    Article  Google Scholar 

  • Peters J (2014) The role of genomic imprinting in biology and disease: an expanding view. Nat Rev Genet 15:517–530

    Article  CAS  Google Scholar 

  • Pluta R, Ułamek-Kozioł M, Januszewski S, Czuczwar S (2019) Amyloid pathology in the brain after ischemia. Folia Neuropathol 57:220–226

    Article  Google Scholar 

  • Ren C, Yao Y, Han R, Huang Q, Li H, Wang B, Li S, Li M, Mao Y, Mao X et al (2018) Cerebral ischemia induces angiogenesis in the peri-infarct regions via Notch1 signaling activation. Exp Neurol 304:30–40

    Article  CAS  Google Scholar 

  • Sato S, Yoshida W, Soejima H, Nakabayashi K, Hata K (2011) Methylation dynamics of IG-DMR and Gtl2-DMR during murine embryonic and placental development. Genomics 98:120–127

    Article  CAS  Google Scholar 

  • Saugstad JA (2015) Non-coding RNAs in stroke and neuroprotection. Front Neurol 6:50

    Article  Google Scholar 

  • Seto SW, Chang D, Jenkins A, Bensoussan A, Kiat H (2016) Angiogenesis in ischemic stroke and angiogenic effects of Chinese herbal medicine. J Clin Med 5(6):5

    Article  Google Scholar 

  • Shan W, Chen W, Zhao X, Pei A, Chen M, Yu Y, Zheng Y, Zhu S (2020) Long noncoding RNA TUG1 contributes to cerebral ischaemia/reperfusion injury by sponging mir-145 to up-regulate AQP4 expression. J Cell Mol Med 24:250–259

    Article  CAS  Google Scholar 

  • Shao HF, Li ZZ, Zheng XF, Wang HJ, Wang YG, Ma ZL, Liu ZB, Han QY (2019) Research on the correlation of changes in plasma lncRNA MEG3 with change in inflammatory factors and prognosis in patients with traumatic brain injury. Eur Rev Med Pharmacol Sci 23:4341–4347

    Google Scholar 

  • Shen J, Zhao Z, Shang W, Liu C, Zhang B, Xu Z, Cai H (2018) Fabrication of a nano polymer wrapping Meg3 ShRNA plasmid for the treatment of cerebral infarction. Artif Cells Nanomed Biotechnol 46:894–903

    Article  CAS  Google Scholar 

  • Sil S, Dagur RS, Liao K, Peeples ES, Hu G, Periyasamy P, Buch S (2019) Strategies for the use of extracellular vesicles for the delivery of therapeutics. J Neuroimmune Pharmacol 15:422–442

    Article  Google Scholar 

  • Smith WS, Furlan AJ (2016) Brief history of endovascular acute ischemic stroke treatment. Stroke 47:e23-26

    Article  Google Scholar 

  • Stoll G, Nieswandt B (2019) Thrombo-inflammation in acute ischaemic stroke - implications for treatment. Nat Rev Neurol 15:473–481

    Article  CAS  Google Scholar 

  • Tan MC, Widagdo J, Chau YQ, Zhu T, Wong JJ, Cheung A, Anggono V (2017) The activity-induced long non-coding RNA Meg3 modulates AMPA receptor surface expression in primary cortical neurons. Front Cell Neurosci 11:124

    Article  Google Scholar 

  • Tian H, Zhou C, Yang J, Li J, Gong Z (2017) Long and short noncoding RNAs in lung cancer precision medicine: opportunities and challenges. Tumour Biol 39:1010428317697578

    Article  Google Scholar 

  • Tsagakis I, Douka K, Birds I, Aspden JL (2020) Long non-coding RNAs in development and disease: conservation to mechanisms. J Pathol 250:480–495

    Article  CAS  Google Scholar 

  • Ulitsky I, Shkumatava A, Jan CH, Sive H, Bartel DP (2011) Conserved function of lincRNAs in vertebrate embryonic development despite rapid sequence evolution. Cell 147:1537–1550

    Article  CAS  Google Scholar 

  • Wang KC, Chang HY (2011) Molecular mechanisms of long noncoding RNAs. Mol Cell 43:904–914

    Article  CAS  Google Scholar 

  • Wang Q, Liu X, Zhu R (2019) Long noncoding RNAs as diagnostic and therapeutic targets for ischemic stroke. Curr Pharm Des 25:1115–1121

    Article  CAS  Google Scholar 

  • Wang M, Chen W, Geng Y, Xu C, Tao X, Zhang Y (2020) Long non-coding RNA MEG3 promotes apoptosis of vascular cells and is associated with poor prognosis in ischemic stroke. J Atheroscler Thromb 27:718–726

    Article  CAS  Google Scholar 

  • Wu Z, Wu P, Zuo X, Yu N, Qin Y, Xu Q, He S, Cen B, Liao W, Ji A (2017) Erratum to: LncRNA-N1LR enhances neuroprotection against ischemic stroke probably by inhibiting p53 phosphorylation. Mol Neurobiol 54:7686–7688

    Article  CAS  Google Scholar 

  • Wylie AA, Murphy SK, Orton TC, Jirtle RL (2000) Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation. Genome Res 10:1711–1718

    Article  CAS  Google Scholar 

  • Xiang Y, Zhang Y, Xia Y, Zhao H, Liu A, Chen Y (2020) LncRNA MEG3 targeting miR-424-5p via MAPK signaling pathway mediates neuronal apoptosis in ischemic stroke. Aging 12:3156–3174

    Article  CAS  Google Scholar 

  • Xu W, Gao L, Zheng J, Li T, Shao A, Reis C, Chen S, Zhang J (2018) The roles of MicroRNAs in stroke: possible therapeutic targets. Cell Transplant 27:1778–1788

    Article  Google Scholar 

  • Yan H, Yuan J, Gao L, Rao J, Hu J (2016) Long noncoding RNA MEG3 activation of p53 mediates ischemic neuronal death in stroke. Neuroscience 337:191–199

    Article  CAS  Google Scholar 

  • Yan H, Rao J, Yuan J, Gao L, Huang W, Zhao L, Ren J (2017) Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate ischemic neuronal death by targeting miR-21/PDCD4 signaling pathway. Cell Death Dis 8:3211

    Article  Google Scholar 

  • Yang J (2019) The role of reactive oxygen species in angiogenesis and preventing tissue injury after brain ischemia. Microvasc Res 123:62–67

    Article  CAS  Google Scholar 

  • Yang J, Chen M, Cao RY, Li Q, Zhu F (2018) The role of circular RNAs in cerebral ischemic diseases: ischemic stroke and cerebral ischemia/reperfusion injury. Adv Exp Med Biol 1087:309–325

    Article  CAS  Google Scholar 

  • Yao P, Li YL, Chen Y, Shen W, Wu KY, Xu WH (2020) Overexpression of long non-coding RNA Rian attenuates cell apoptosis from cerebral ischemia-reperfusion injury via Rian/miR-144-3p/GATA3 signaling. Gene 737:144411

    Article  CAS  Google Scholar 

  • Yin KJ, Hamblin M, Chen YE (2015) Angiogenesis-regulating microRNAs and ischemic stroke. Curr Vasc Pharmacol 13:352–365

    Article  CAS  Google Scholar 

  • You D, You H (2019) Repression of long non-coding RNA MEG3 restores nerve growth and alleviates neurological impairment after cerebral ischemia-reperfusion injury in a rat model. Biomed Pharmacother 111:1447–1457

    Article  CAS  Google Scholar 

  • Yu SY, Tang L, Zhou SH (2018) Long noncoding RNAs: new players in ischaemia-reperfusion injury. Heart Lung Circ 27:322–332

    Article  Google Scholar 

  • Zeniya S, Kuwahara H, Daizo K, Watari A, Kondoh M, Yoshida-Tanaka K, Kaburagi H, Asada K, Nagata T, Nagahama M et al (2018) Angubindin-1 opens the blood-brain barrier in vivo for delivery of antisense oligonucleotide to the central nervous system. J Control Release 283:126–134

    Article  CAS  Google Scholar 

  • Zhan R, Xu K, Pan J, Xu Q, Xu S, Shen J (2017) Long noncoding RNA MEG3 mediated angiogenesis after cerebral infarction through regulating p53/NOX4 axis. Biochem Biophys Res Commun 490:700–706

    Article  CAS  Google Scholar 

  • Zhang X, Zhou Y, Mehta KR, Danila DC, Scolavino S, Johnson SR, Klibanski A (2003) A pituitary-derived MEG3 isoform functions as a growth suppressor in tumor cells. J Clin Endocrinol Metab 88:5119–5126

    Article  CAS  Google Scholar 

  • Zhang X, Gejman R, Mahta A, Zhong Y, Rice KA, Zhou Y, Cheunsuchon P, Louis DN, Klibanski A (2010) Maternally expressed gene 3, an imprinted noncoding RNA gene, is associated with meningioma pathogenesis and progression. Cancer Res 70:2350–2358

    Article  CAS  Google Scholar 

  • Zhang J, Yuan L, Zhang X, Hamblin MH, Zhu T, Meng F, Li Y, Chen YE, Yin KJ (2016) Altered long non-coding RNA transcriptomic profiles in brain microvascular endothelium after cerebral ischemia. Exp Neurol 277:162–170

    Article  CAS  Google Scholar 

  • Zhang X, Tang X, Hamblin MH, Yin KJ (2018) Long non-coding RNA Malat1 regulates angiogenesis in hindlimb ischemia. Int J Mol Sci 19(6):1723

    Article  Google Scholar 

  • Zhang WF, Jin YC, Li XM, Yang Z, Wang D, Cui JJ (2019a) Protective effects of leptin against cerebral ischemia/reperfusion injury. Exp Ther Med 17:3282–3290

    CAS  Google Scholar 

  • Zhang X, Zhu XL, Ji BY, Cao X, Yu LJ, Zhang Y, Bao XY, Xu Y, Jin JL (2019b) LncRNA-1810034E14Rik reduces microglia activation in experimental ischemic stroke. J Neuroinflammation 16:75

    Article  Google Scholar 

  • Zhang Y, Zhang L, Wang Y, Ding H, Xue S, Qi H, Li P (2019c) MicroRNAs or long noncoding RNAs in diagnosis and prognosis of coronary artery disease. Aging Dis 10:353–366

    Article  Google Scholar 

  • Zhao F, Qu Y, Liu J, Liu H, Zhang L, Feng Y, Wang H, Gan J, Lu R, Mu D (2015) Microarray profiling and co-expression network analysis of LncRNAs and mRNAs in neonatal rats following hypoxic-ischemic brain damage. Sci Rep 5:13850

    Article  Google Scholar 

  • Zhao Y, Zhang Y, Zhang L, Dong Y, Ji H, Shen L (2019) The potential markers of circulating microRNAs and long non-coding RNAs in Alzheimer’s disease. Aging Dis 10:1293–1301

    Article  Google Scholar 

  • Zhao F, Xing Y, Jiang P, Hu L, Deng S (2021) LncRNA MEG3 inhibits the proliferation of neural stem cells after ischemic stroke via the miR-493-5P/MIF axis. Biochem Biophys Res Commun 568:186–192

    Article  CAS  Google Scholar 

  • Zheng Z, Liu S, Wang C, Han X (2018) A functional polymorphism rs145204276 in the promoter of long noncoding RNA GAS5 is associated with an increased risk of ischemic stroke. J Stroke Cerebrovasc Dis 27:3535–3541

    Article  Google Scholar 

  • Zheng H, Li BH, Liu C, Jia L, Liu FT (2020) Comprehensive analysis of lncRNA-mediated ceRNA crosstalk and identification of prognostic biomarkers in Wilms’ tumor. Biomed Res Int 2020:4951692

    Google Scholar 

  • Zhou Y, Zhang X, Klibanski A (2012) MEG3 noncoding RNA: a tumor suppressor. J Mol Endocrinol 48:R45-53

    Article  CAS  Google Scholar 

  • Zhou R, Chen KK, Zhang J, Xiao B, Huang Z, Ju C, Sun J, Zhang F, Lv XB, Huang G (2018a) The decade of exosomal long RNA species: an emerging cancer antagonist. Mol Cancer 17:75

    Article  Google Scholar 

  • Zhou XM, Liu J, Wang Y, Zhang MH (2018b) Silencing of long noncoding RNA MEG3 enhances cerebral protection of dexmedetomidine against hypoxic-ischemic brain damage in neonatal mice by binding to miR-129-5p. J Cell Biochem. https://doi.org/10.1002/jcb.28075

    Article  Google Scholar 

  • Zhou H, Wang B, Yang YX, Jia QJ, Zhang A, Qi ZW, Zhang JP (2019a) Long noncoding RNAs in pathological cardiac remodeling: a review of the update literature. Biomed Res Int 2019:7159592

    Article  Google Scholar 

  • Zhou ZW, Zheng LJ, Ren X, Li AP, Zhou WS (2019b) LncRNA NEAT1 facilitates survival and angiogenesis in oxygen-glucose deprivation (OGD)-induced brain microvascular endothelial cells (BMECs) via targeting miR-377 and upregulating SIRT1, VEGFA, and BCL-XL. Brain Res 1707:90–98

    Article  CAS  Google Scholar 

  • Zhu R, Xiao T, Wang Q, Zhao Y, Liu X (2021) Genetic polymorphisms in lncRNAs predict recurrence of ischemic stroke. Metab Brain Dis 36:1353–1359

    Article  CAS  Google Scholar 

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Funding

This work was supported by the National Natural Science Foundation of China (Grant Numbers 31900694).

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  1. Institute of Biomedical Research, Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Zibo Key Laboratory of New Drug Development of Neurodegenerative Diseases, School of Life Sciences and Medicine, Shandong University of Technology, Zibo, China

    Yanfang Zhao, Qili Zhang, Hongliang Liu & Jianing Xu

  2. Institute of Translational Medicine, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China

    Yingying Liu

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  1. Yanfang Zhao
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YZ designed and wrote the initial manuscript. YL, QZ, HL and JX made the revision. All authors approved the final manuscript as submitted.

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Correspondence to Yanfang Zhao.

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Zhao, Y., Liu, Y., Zhang, Q. et al. The Mechanism Underlying the Regulation of Long Non-coding RNA MEG3 in Cerebral Ischemic Stroke. Cell Mol Neurobiol 43, 69–78 (2023). https://doi.org/10.1007/s10571-021-01176-2

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