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Long non-coding RNAs and cell death following ischemic stroke

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Abstract

Stroke is a major cause of morbidity and mortality worldwide, and extensive efforts have focused on the improvement of therapeutic strategies to reduce cell death following ischemic stroke. Uncovering the cellular and molecular pathophysiological processes in ischemic stroke have been a top priority. Long noncoding RNAs (lncRNAs) are endogenous molecules that play key roles in the pathophysiology of cerebral ischemia, and involved in the neuronal cell death during ischemic stroke. In recent years, a bulk of aberrantly expressed lncRNAs have been screened out in ischemic stroke insulted animals. LncRNAs along with their targets could affect the genetic machinery at molecular levels, and exploring their functions and mechanisms may be a promising option for ischemic stroke treatment. In this review, we summarize the current knowledge for lncRNAs in ischemic stroke, focusing on the role of specific lncRNAs that may underlie cell death to find possible therapeutic targets.

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Authors and Affiliations

  1. Department of Biology, Tehran North Branch, Islamic Azad University, Tehran, Iran

    Masoumeh Alishahi & Tannaz Akbari Kolagar

  2. Department of Immunology, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran

    Farhoodeh Ghaedrahmati

  3. Dipartimento di Biologia, Università degli Studi di Napoli, Federico II, Via Cintia 26, 80126, Naples, Italy

    William Winlow

  4. Honorary Research Fellow, Institute of Ageing and Chronic Diseases, University of Liverpool, The APEX building, 6 West Derby Street, Liverpool, L7 8TX, UK

    William Winlow

  5. Department of Biology, Faculty of Sciences, Alzahra University, Tehran, Iran

    Negin Nikkar

  6. Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran

    Maryam Farzaneh

  7. Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Seyed Esmaeil Khoshnam

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  1. Masoumeh Alishahi
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Alishahi, M., Ghaedrahmati, F., Kolagar, T.A. et al. Long non-coding RNAs and cell death following ischemic stroke. Metab Brain Dis 34, 1243–1251 (2019). https://doi.org/10.1007/s11011-019-00423-2

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