Abstract
The Hippo signaling pathway is highly conserved from Drosophila melanogaster to mammals and plays a crucial role in organ size control, tissue regeneration, and tumor suppression. The Yes-associated protein (YAP) is an important transcriptional co-activator that is negatively regulated by the Hippo signaling pathway. The Hippo signaling pathway is also regulated by various upstream regulators, such as cell polarity, adhesion proteins, and other signaling pathways (the Wnt/β-catenin, Notch, and MAPK pathways). Recently, accumulated evidence suggests that the Hippo/YAP signaling pathway plays important roles in central nervous system development and brain tumor, including glioma. In this review, we summarize the results of recent studies on the physiological effect of the Hippo/YAP signaling pathway in neural stem cells, neural progenitor cells, and glial cells. In particular, we also focus on the expression of MST1/2, LATS1/2, and the downstream effector YAP, in glioma, and offer a review of the latest research of the Hippo/YAP signaling pathway in glioma pathogenesis. Finally, we also present future research directions and potential therapeutic strategies for targeting the Hippo/YAP signaling in glioma.
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Abbreviations
- YAP:
-
YES-associated protein
- MST:
-
Mammalian STE20-like protein kinase
- LATS:
-
Large tumor suppressor
- KIBRA:
-
Kidney and brain protein
- NF2:
-
Neurofibromin 2
- GPCR:
-
G protein-coupled receptor
- S1P:
-
Sphingosine 1-phosphate
- LPA:
-
Lysophosphatidic acid
- PKC:
-
Protein kinase C
- NSCs:
-
Neural stem cells
- ECM:
-
Extracellular matrix
- hPSC:
-
Human pluripotent stem cell
- NPC:
-
Neural progenitor cell
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The present study was supported by the National Natural Science Foundation of China (Grant No. 81760447).
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Ouyang, T., Meng, W., Li, M. et al. Recent Advances of the Hippo/YAP Signaling Pathway in Brain Development and Glioma. Cell Mol Neurobiol 40, 495–510 (2020). https://doi.org/10.1007/s10571-019-00762-9
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DOI: https://doi.org/10.1007/s10571-019-00762-9