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Dynamic interaction between the growing Ca–P minerals and bacterial cellulose nanofibers during early biomineralization process

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Abstract

Bone is a composite of organic phase (collagen nanofibers) and Ca–P minerals (hydroxylapatite) and an important biological structure in the field of biomineralization, but the interaction between organic matrixes and inorganic minerals is still too ambiguous. In order to investigate the interaction between the growing Ca–P minerals and organic nanofibers during early biomineralization process, bacterial cellulose (BC) nanofibers were used as templates to mimic collagen nanofibers for Ca–P minerals deposition via biomineralization for periods from as short as 4–72 h. Our findings pointed out that the resultant Ca–P minerals formed on BC nanofibers were platelet-like calcium-deficient HAp which was analogous to those in natural bone tissue. Strikingly, we found that the growth of Ca–P minerals had influence on the structure and properties of BC nano-templates during biomineralization process.

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Acknowledgments

This work is supported by the National Natural Science Foundation of China (Grants 50872088, 50673076 and 50539060). Financial support was also from the State Key Basic Research (973) Program (Grant 2007CB936100) and the National Hi-Tech Research Development (863) Program (2009AA03Z311). The authors also thank Prof. Han Ming, postgraduate students Sun Ruitao, Yu Zhonghui and undergraduate student Dong Shuo from Shandong University of Technology for TEM analysis assistance.

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Authors and Affiliations

  1. School of Materials Science and Engineering, and Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, 300072, Tianjin, People’s Republic of China

    Chuan Gao, Hong Lin Luo, Yuan Huang & Yi Zao Wan

  2. School of Mechanical and Electrical Engineering, East China Jiaotong University, 330013, Nanchang, Jiangxi, People’s Republic of China

    Guang Yao Xiong

  3. Department of Joint Surgery, Tianjin Hospital, 300211, Tianjin, People’s Republic of China

    Kai Jing Ren

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  1. Chuan Gao
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  2. Guang Yao Xiong
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  3. Hong Lin Luo
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  5. Yuan Huang
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  6. Yi Zao Wan
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Correspondence to Yi Zao Wan.

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Gao, C., Xiong, G.Y., Luo, H.L. et al. Dynamic interaction between the growing Ca–P minerals and bacterial cellulose nanofibers during early biomineralization process. Cellulose 17, 365–373 (2010). https://doi.org/10.1007/s10570-009-9371-4

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