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Polymer Supported Ferric Chloride as Heterogeneous Catalyst for Three Component Biginelli Reaction

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Abstract

Polymer supported ferric chloride catalyst is prepared and characterized by IR, SEM, TEM, EDS, TGA, ICP-MS and XRD. The heterogenized Lewis acid catalyst was found to efficiently promote three component Biginelli reaction, where the 3,4-dihydropyrimidine-2(1H)-ones/thiones were efficiently synthesized from urea/thiourea. The catalyst was found to be quite robust for this reaction with very less leaching of metal was observed, and hence can be efficiently recycled. The catalyst was found to be effective for multiple uses, establishing its reusability in this important reaction.

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Acknowledgements

The authors are thankful to the Head, Department of Chemistry, The Maharaja Sayajirao University of Baroda, Vadodara for providing necessary laboratory facilities. The funding agency Science and Engineering Research Board, Department of Science and Technology (Award no: EEQ/2022/000473) and Research and Development Cell, The Maharaja Sayajirao University of Baroda (Award no: RDC/Dir./2023-24/19/17) for financially supporting to the corresponding author.

Funding

The funding was provided by Science and Engineering Research Board, Department of Science and Technology (Grant No: EEQ/2022/000473), and Research and Development Cell, The Maharaja Sayajirao University of Baroda (Grant No: RDC/Dir./2023-24/19/17)

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  1. Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, 390 002, India

    Akash V. Gujarati, Ashutosh V. Bedekar, Arun L. Patel & Divyesh K. Patel

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Gujarati, A.V., Bedekar, A.V., Patel, A.L. et al. Polymer Supported Ferric Chloride as Heterogeneous Catalyst for Three Component Biginelli Reaction. Catal Lett (2024). https://doi.org/10.1007/s10562-024-04624-y

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