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High-Performance Pd/AC Catalyst for Meropenem Synthesis Based on Selective Surface Modification of Activated Carbon

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Abstract

Activated carbon (AC) was treated with nitric acid, hydrogen peroxide, and urea. The obtained products were then used as supports for the preparation of palladium/activated carbon (Pd/AC) catalysts. The characterization results revealed that the AC textural structure and surface properties were selectively modified via different treatments, and the surface functional groups of the supports could affect the particle size, dispersion, and chemical states of the Pd nanoparticles. The surface of the urea-treated AC (AC-U) contained more carbonylic groups and nitrogenous species but fewer hydroxylic and carboxylic groups than the surfaces of the ACs subjected to other treatments. Consequently, in the hydrogenation synthesis of meropenem, the Pd/AC-U catalyst provided a higher meropenem yield and lower amounts of impurities in the meropenem product than the other catalysts. The nitrogenous groups not only provided efficient anchoring sites for Pd nanoparticles, improving the reaction activity, but also reduced the side reactions, decreasing the impurity content in the product.

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Acknowledgements

This work was financially supported by the Innovative Talent Promotion Plan—Youth Science and Technology New Star Program of Shaanxi Province of China (2018KJXX-074), the Guidance of Technology Innovation in Shaanxi Province of China (2019CGHJ-04), and the Innovation Capability Support Program of Shaanxi Province of China (2020TD-007). We thank LetPub (www.letpub.com) for its linguistic assistance during the preparation of this manuscript.

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Authors and Affiliations

  1. School of Science, Xi’an Jiaotong University, Xi’an, 710049, Shaanxi, P. R. China

    Yuefeng Li, Shujuan Wang & Xinli Jing

  2. Department of Technology, Kaili Catalyst & New Materials Co., Ltd., Xi’an, 710201, Shaanxi, P. R. China

    Yuefeng Li, Zhaowen Wang, Jiangmei Yan & Zhixiang Zhang

  3. Department of Pharmacy, Xi’an Children’s Hospital, Xi’an, 710004, Shaanxi, P. R. China

    Fengmei Xiong

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  1. Yuefeng Li
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Li, Y., Xiong, F., Wang, Z. et al. High-Performance Pd/AC Catalyst for Meropenem Synthesis Based on Selective Surface Modification of Activated Carbon. Catal Lett 152, 2078–2089 (2022). https://doi.org/10.1007/s10562-021-03783-6

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